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Titolo:
Evidence for evolutionary conservation of a physical linkage between the human BAF60b, a subunit of SWI SNF complex, and thyroid hormone receptor interacting protein-1 genes on chromosome 17
Autore:
Surabhi, RM; Daly, LD; Cattini, PA;
Indirizzi:
Univ Manitoba, Dept Physiol, Winnipeg, MB R3E 3J7, Canada Univ Manitoba Winnipeg MB Canada R3E 3J7 ol, Winnipeg, MB R3E 3J7, Canada
Titolo Testata:
GENOME
fascicolo: 3, volume: 42, anno: 1999,
pagine: 545 - 549
SICI:
0831-2796(199906)42:3<545:EFECOA>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAMMALIAN SWI/SNF COMPLEXES; MUSCLE SODIUM-CHANNEL; TAT-BINDING PROTEIN; GROWTH-HORMONE; SKELETAL-MUSCLE; TRANSCRIPTION FACTOR; ALPHA-SUBUNIT; FAMILY; LOCUS; RAT;
Keywords:
P1 clone; gene mapping; downstream gene;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Cattini, PA Univ Manitoba, Dept Physiol, Winnipeg, MB R3E 3J7, Canada UnivManitoba Winnipeg MB Canada R3E 3J7 , MB R3E 3J7, Canada
Citazione:
R.M. Surabhi et al., "Evidence for evolutionary conservation of a physical linkage between the human BAF60b, a subunit of SWI SNF complex, and thyroid hormone receptor interacting protein-1 genes on chromosome 17", GENOME, 42(3), 1999, pp. 545-549

Abstract

The ubiquitously expressed rat BAF60b gene, which codes for a subunit of the multiprotein SWI/SNF complex, was recently identified between the pituitary growth hormone (GH-N) and thyroid hormone receptor interacting protein-1 (TRIP-1) genes. In primates, duplication of the GH-N gene has resulted inthe addition of four placenta-specific (GH-V, CS-A, CS-B, and CS-L) genes downstream of the GH-N gene. As part of our study of the effect of remote sequences on the transcriptional regulation of the GH/CS gene family, we showed recently that these genes lie 40 kb upstream of the human TRIP-1 gene. We have now investigated the presence of the human BAF60b gene upstream of the TRIP-1 gene for evidence of evolutionary conservation of this arrangement or its disruption by the recent duplication of the nearby GH-N gene in primates. We report that, as in the rat genome, the human BAF60b gene is in the reverse transcriptional direction relative to the TRIP-1 gene, such that their polyadenylation sites are separated by 93 bp which compares with 92bp in the fat. Reexamination of reported porcine TRIP-1 sequences also revealed the presence of the BAF60b gene separated by 93 bp, supporting an evolutionary conservation of this arrangement.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 17:16:19