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Titolo:
The role of Na+-H+ exchange in fluid and solute transport in the rat efferent ducts
Autore:
Hansen, LA; Clulow, J; Jones, RC;
Indirizzi:
Univ Newcastle, Dept Biol Sci, Newcastle, NSW 2308, Australia Univ Newcastle Newcastle NSW Australia 2308 ewcastle, NSW 2308, Australia
Titolo Testata:
EXPERIMENTAL PHYSIOLOGY
fascicolo: 3, volume: 84, anno: 1999,
pagine: 521 - 527
SICI:
0958-0670(199905)84:3<521:TRONEI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROXIMAL CONVOLUTED TUBULE; CARBONIC-ANHYDRASE; NACL ABSORPTION; MACROPUS-EUGENII; EXCURRENT DUCTS; TESTIS; EPIDIDYMIS; ACIDIFICATION; SECRETION; DIFFERENTIATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Clulow, J Univ Newcastle, Dept Biol Sci, Newcastle, NSW 2308, Australia Univ Newcastle Newcastle NSW Australia 2308 NSW 2308, Australia
Citazione:
L.A. Hansen et al., "The role of Na+-H+ exchange in fluid and solute transport in the rat efferent ducts", EXP PHYSIOL, 84(3), 1999, pp. 521-527

Abstract

In vivo microperfusion techniques were used to investigate the role of Na+-H+ exchange in the efferent ducts of the rat. Individual efferent ducts were perfused with a Krebs-Ringer bicarbonate solution (KRB) containing 0, 1,3, 5 or 7.5 mM amiloride. Concentrations of 1-5 mM amiloride inhibited fluid reabsorption from the efferent ducts in a linear dose-dependent manner with an apparent K-m of 3 mM. Inhibition was maximal at 5 mM with reabsorption reduced by about 70 %. The effects of amiloride were completely reversible and there was little effect of amiloride on luminal osmolality and concentrations of Na+, Cl- or K+. It is concluded that Na+-H+ exchange is one ofthe principal mechanisms responsible for fluid and electrolyte reabsorption in the efferent ducts and offers a means by which the efferent ducts are able to achieve flow-dependent, autoregulated fluid reabsorption.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 15:41:04