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Titolo:
Exogenous surfactant improves survival and surfactant function in ischaemia-reperfusion injury in minipigs
Autore:
Hohlfeld, JM; Struber, M; Ahlf, K; Hoeper, MM; Fraund, S; Krug, N; Warnecke, G; Harringer, W; Haverich, A; Fabel, H;
Indirizzi:
Hannover Med Sch, Dept Resp Med, D-30625 Hannover, Germany Hannover Med Sch Hannover Germany D-30625 Med, D-30625 Hannover, Germany Hannover Med Sch, Dept Thorac & Cardiovasc Surg, D-30625 Hannover, GermanyHannover Med Sch Hannover Germany D-30625 urg, D-30625 Hannover, Germany
Titolo Testata:
EUROPEAN RESPIRATORY JOURNAL
fascicolo: 5, volume: 13, anno: 1999,
pagine: 1037 - 1043
SICI:
0903-1936(199905)13:5<1037:ESISAS>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY-DISTRESS-SYNDROME; EXPERIMENTAL LUNG TRANSPLANTATION; PULMONARY SURFACTANT; PRESERVATION; PROTEINS; EDEMA; INACTIVATION; INHIBITION; THERAPY;
Keywords:
exogenous surfactant treatment; lung transplantation; pulmonary surfactant; reperfusion injury; surfactant dysfunction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Hohlfeld, JM Hannoveranyd Sch, Dept Resp Med, Carl Neuberg Str 1, D-30625 Hannover, Germ Hannover Med Sch Carl Neuberg Str 1 Hannover Germany D-30625
Citazione:
J.M. Hohlfeld et al., "Exogenous surfactant improves survival and surfactant function in ischaemia-reperfusion injury in minipigs", EUR RESP J, 13(5), 1999, pp. 1037-1043

Abstract

Reperfusion injury is the major cause of early morbidity and mortality after lung transplantation. This complication has been experimentally linked to dysfunction of pulmonary surfactant. Therefore, the hypothesis that reperfusion injury might be preventable by exogenous surfactant treatment was tested. Left lungs of minipigs were exposed to 120 min of ischaemia, and the lungswere then reperfused for up to 7 h. Animals were divided into a control group and a surfactant group (n=5 each). The surfactant group received 50 mg.kg(-1) Alveofact(R) intrabronchially via a bronchoscope at the beginning ofthe ischaemic period. Bronchoalveolar lavage was performed at baseline before ischaemia and 90 min after reperfusion. Surfactant treatment significantly improved short-term survival. Pulmonaryvascular resistance increased markedly in control animals Leading to rightheart failure and death within 3 h after reperfusion whereas the surfactant-treated animals survived the 7 h observation period. After reperfusion, alveolar accumulation of neutrophils and exuded proteins was present in bothgroups to the same extent. Surfactant activity after reperfusion deteriorated markedly in the control group but was preserved in the surfactant group. In conclusion, early surfactant treatment alleviates the deterioration of surfactant function and improves survival in this minipig model of ischaemia-reperfusion injury.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 22:18:32