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Titolo:
Effects of NMDA receptor antagonists on morphine tolerance: a c-Fos study in the lumbar spinal cord of the rat
Autore:
Le Guen, S; Catheline, G; Besson, JM;
Indirizzi:
INSERM,eU161, Unite Rech Physiopharmacol Syst Nerveux, F-75014 Paris, Franc INSERM Paris France F-75014 pharmacol Syst Nerveux, F-75014 Paris, Franc EPHE, F-75014 Paris, France EPHE Paris France F-75014EPHE, F-75014 Paris, France
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 1, volume: 373, anno: 1999,
pagine: 1 - 11
SICI:
0014-2999(19990528)373:1<1:EONRAO>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
OPIOID TOLERANCE; PHYSICAL-DEPENDENCE; ANTINOCICEPTIVE TOLERANCE; COMPETITIVE ANTAGONIST; SYSTEMIC MORPHINE; OPIATE TOLERANCE; MK-801 BLOCKS; NEONATAL RAT; DORSAL HORN; EXPRESSION;
Keywords:
c-Fos; spinal cord; inflammation; NMDA receptor antagonist; tolerance; morphine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
67
Recensione:
Indirizzi per estratti:
Indirizzo: Le Guen, S INSERM,4U161, Unite Rech Physiopharmacol Syst Nerveux, 2 Rue Alesia, F-7501 INSERM 2 Rue Alesia Paris France F-75014 2 Rue Alesia, F-7501
Citazione:
S. Le Guen et al., "Effects of NMDA receptor antagonists on morphine tolerance: a c-Fos study in the lumbar spinal cord of the rat", EUR J PHARM, 373(1), 1999, pp. 1-11

Abstract

This study investigated the contribution of NMDA receptors to the development of tolerance to the antinociceptive properties of morphine at the levelof the spinal cord dorsal horn. The expression of c-Fos protein following intraplantar (i.pl.) injection of carrageenin (6 mg/150 mu l of saline) wasused. In naive rats, acute intravenous (i.v.) administration of morphine (3 mg/kg) decreased the total number per section of Fos-Like-Immunoreactive (Fos-LI) neurons by 51%, observed at 2 h after injection of carrageenin. Intolerant rats, acute morphine did not significantly modify the total number of Fos-like immunoreactive neurons/section. In rats receiving chronic morphine and chronic injections of the non-competitive ((+)-MK 801 maleate: (SR,10S)-(+)-5-methyl-10,11-dihydro-5H-dibenzo [a,d]cyclohepten-5,10-imine) or the competitive (LY 235959: [3S-(3 alpha,4a alpha,6 beta,8a beta)]-Decahydro-6-(phosphonomethyl)-3-isoquinolinecarboxylic acid) NMDA receptor antagonists, only partial tolerance to the acute effects of morphine were observed (decrease of 42% and 38%, respectively). Administration of an antagonist at the strychnine-insensitive glycine site of the NMDA receptor ((+)-HA-966: R(+)-3-Amino-1-hydroxypyrrolidin-2-one) did not affect the development ofmorphine tolerance. These findings suggest that compounds attenuating the actions of the NMDA receptor via blockade of the glycine modulatory site may be substantially different from those acting at the ion channel of the NMDA receptor complex. This in vivo experiment in freely moving animals demonstrates for the first time an attenuation of tolerance at the cellular level. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 12:45:31