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Titolo:
Use of herpes simplex virus type I for transgene expression within the nervous system
Autore:
Lachmann, RH; Efstathiou, S;
Indirizzi:
Univ Cambridge, Dept Pathol, Div Virol, Cambridge CB2 1QP, England Univ Cambridge Cambridge England CB2 1QP rol, Cambridge CB2 1QP, England Addenbrookes Hosp, Dept Med, Cambridge CB2 2QQ, England Addenbrookes HospCambridge England CB2 2QQ , Cambridge CB2 2QQ, England
Titolo Testata:
CLINICAL SCIENCE
fascicolo: 6, volume: 96, anno: 1999,
pagine: 533 - 541
SICI:
0143-5221(199906)96:6<533:UOHSVT>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
LATENTLY INFECTED MICE; TYROSINE-HYDROXYLASE PROMOTER; REPORTER GENE-EXPRESSION; LONG-TERM EXPRESSION; DORSAL-ROOT GANGLIA; RNA-POLYMERASE-I; BETA-GALACTOSIDASE; NEUROLOGICAL DISORDERS; TRIGEMINAL GANGLION; DNA-SEQUENCES;
Keywords:
gene therapy; herpes simplex virus; neuronal gene delivery; viral vectors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Lachmann, RH Univ Cambridge, Dept Pathol, Div Virol, Tennis Court Rd, Cambridge CB2 1QP, Univ Cambridge Tennis Court Rd Cambridge England CB2 1QP QP,
Citazione:
R.H. Lachmann e S. Efstathiou, "Use of herpes simplex virus type I for transgene expression within the nervous system", CLIN SCI, 96(6), 1999, pp. 533-541

Abstract

Gene therapy might provide a useful treatment for a number of neurologicaldiseases and a great deal of effort is going into the development of vector systems which will allow the delivery of potentially therapeutic genes toterminally differentiated neurons within the intact mammalian brain. The ability of herpes simplex virus type I (HSV-I) to establish a lifelong latent infection within neurons has led to interest in its use as a neuronal gene delivery vector. During HSV latency no viral proteins are produced and transcription from the latent viral genome is limited to a family of nuclear RNAs, the latency-associated transcripts, whose function is not well understood. Obtaining prolonged expression of a transgene in latently infected neurons has proven difficult due to transcriptional silencing of exogenous promoters introduced into the latent viral genome. For this reason there is agreat deal of interest in utilizing the HSV latency-associated promoter todrive the expression of therapeutic genes in latently infected neurons of both the peripheral and central nervous systems. In this review we describea strategy which allows the latency-associated promoter to drive long-termreporter gene expression in the mammalian nervous system. These observations open up the possibility of using similar HSV-based vectors to express therapeutic transgenes within the brain and investigate the potential of genetherapy in a range of neurological disorders.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 07:05:50