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Titolo:
A 20-year epidemiological study of pneumococcal meningitis
Autore:
Stanek, RJ; Mufson, MA;
Indirizzi:
Marshall Univ, Sch Med, Dept Med, Huntington, WV 25701 USA Marshall Univ Huntington WV USA 25701 Dept Med, Huntington, WV 25701 USA
Titolo Testata:
CLINICAL INFECTIOUS DISEASES
fascicolo: 6, volume: 28, anno: 1999,
pagine: 1265 - 1272
SICI:
1058-4838(199906)28:6<1265:A2ESOP>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESISTANT STREPTOCOCCUS-PNEUMONIAE; ACUTE BACTERIAL-MENINGITIS; PENICILLIN-RESISTANT; UNITED-STATES; SUSCEPTIBILITY TEST; CONJUGATE VACCINE; HAEMOPHILUS-INFLUENZAE; CEREBROSPINAL-FLUID; CHILDREN; IMMUNOGENICITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Mufson, MA MarshallVUniv, Sch Med, Dept Med, 1600 Med Ctr Dr,Suite G500, Huntington, W Marshall Univ 1600 Med Ctr Dr,Suite G500 Huntington WV USA 25701
Citazione:
R.J. Stanek e M.A. Mufson, "A 20-year epidemiological study of pneumococcal meningitis", CLIN INF D, 28(6), 1999, pp. 1265-1272

Abstract

We conducted a retrospective analysis of 55 community-acquired Streptococcus pneumoniae meningitis illnesses in Huntington, West Virginia, from 1978 to 1997. Fourteen (36.8%) of 38 adults and 2 (11.8%) of 17 children died. Serotypes 6, 23, 3, and 18 accounted for 20 (41.7%) of 48 strains available for serotyping. Of 40 strains available for antimicrobial susceptibility testing, 1 serotype 19 and 1 serotype 23 strain showed intermediate resistance and a second serotype 23 strain showed high resistance to penicillin; allthree patients survived. The case-fatality rates among adults who receivedpenicillin alone, gentamicin in combination, or vancomycin and cephalosporin together were 57.1%, 55.5%, and 60%, respectively, and among those who received chloramphenicol or a third-generation cephalosporin, they were 11.1% or nil, respectively. No child died who received chloramphenicol or vancomycin. Two (33%) of 6 children died who received a third-generation cephalosporin; both were critically ill when initially treated. No child and one adult had received pneumococcal vaccine prior to becoming ill.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 10:41:41