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Titolo:
Sodium fluorescein influence on the hemorheological profile of non-insulindependent diabetes mellitus patients
Autore:
Sargento, L; Zabala, L; Saldanha, C; Souza-Ramalho, P; Martins-Silva, J;
Indirizzi:
Fac Med Lisboa, Inst Bioquim & Quim Fisiol, P-1600 Lisbon, Portugal Fac Med Lisboa Lisbon Portugal P-1600 im Fisiol, P-1600 Lisbon, Portugal Fac Med Lisboa, Clin Univ Oftalmol, P-1600 Lisbon, Portugal Fac Med Lisboa Lisbon Portugal P-1600 Oftalmol, P-1600 Lisbon, Portugal
Titolo Testata:
CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
fascicolo: 2, volume: 20, anno: 1999,
pagine: 77 - 84
SICI:
1386-0291(1999)20:2<77:SFIOTH>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACCUMULATION; ANGIOGRAPHY; CELLS;
Keywords:
non-insulin dependent diabetes mellitus; sodium fluorescein; erythrocyte aggregation; erythrocyte deformability; whole blood viscosity; carboxyhemoglobin; methemoglobin; erythrocyte membrane fluidity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Sargento, L Fac Med Lisboa, Inst Bioquim, Av Prof Egas Moniz, P-1600 Lisbon, Portugal Fac Med Lisboa Av Prof Egas Moniz Lisbon Portugal P-1600 ugal
Citazione:
L. Sargento et al., "Sodium fluorescein influence on the hemorheological profile of non-insulindependent diabetes mellitus patients", CL HEMORH M, 20(2), 1999, pp. 77-84

Abstract

Sodium fluorescein angiography is a widely used technology in ophthalmology, which allows us to visualise the chorioretinal microcirculation. Previous reports showed a prolongation of the retinal circulation time along with erythrocyte hyperaggregation and a decrease of erythrocyte acetylcholinesterase activity and a possible interference with the erythrocyte's membrane fluidity. The aim of the present work is to investigate the influence of sodium fluorescein on the hemorheological profile of a group of 23 non-insulindependent diabetes mellitus (NIDDM) patients undergoing routine retinal angiography. Thirty minutes after the endovenous administration of the fluorescein there was: (I) an increase of whole blood viscosity (p = 0.015), erythrocyte elongation index (EEI, p < 0.05), whole blood pH (p < 0.001), methemoglobin (p < 0.001) and carboxyhemoglobin (p < 0.001) concentrations; (II) no variation of plasma osmolality and erythrocyte aggregation index (EAI); (III) a decrease of the erythrocyte acetylcholinesterase activity, p < 001; (IV) no variation in membrane lipid fluidity, although 1,6-diphenyl-1,3,5-hexatriene (DPH) correlated directly with the EEI, while 1,4-trimethyl-phenyl-1,3,5-hexatriene (TMA-DPH) and EAI correlated inversely, suggesting that the decreasing EEI (lower erythrocyte deformablity) might be associated with an increased rigidity of the external polar region and fluidification of the hydrophobic region of the erythrocyte membrane, with an increasing EAI. In conclusion, the endovenous administration of sodium fluorescein in NIDDM patients during the retinal angiography procedure interferes with the erythrocyte membrane and possibly with the microcirculatory blood flow.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 23:23:54