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Titolo:
Antitumor activity of four macrocyclic ellagitannins from Cuphea hyssopifolia
Autore:
Wang, CC; Chen, LG; Yang, LL;
Indirizzi:
TaipeiTaiwanoll, Grad Inst Pharmaceut Sci, Dept Pharmacognosy, Taipei 110,Taipei Med Coll Taipei Taiwan 110 t Sci, Dept Pharmacognosy, Taipei 110,
Titolo Testata:
CANCER LETTERS
fascicolo: 1-2, volume: 140, anno: 1999,
pagine: 195 - 200
SICI:
0304-3835(19990601)140:1-2<195:AAOFME>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
TANNINS; POLYPHENOLS;
Keywords:
oenothein B; woodfordin C; cuphiin D-1; cuphiin D-2; antitumor activity in vivo and in vitro;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Yang, LL Taipei Med Coll, Grad Inst Pharmaceut Sci, Dept Pharmacognosy, 250 Wu Hsing Taipei Med Coll 250 Wu Hsing St Taipei Taiwan 110 , 250 Wu Hsing
Citazione:
C.C. Wang et al., "Antitumor activity of four macrocyclic ellagitannins from Cuphea hyssopifolia", CANCER LETT, 140(1-2), 1999, pp. 195-200

Abstract

We evaluated the antitumor activities of four macrocyclic hydrolyzable tannin dimers, cuphiin D-1, cuphiin D-2, oenothein B and woodfordin C isolatedfrom Cuphea hyssopifolia (Lythraceae). All significantly inhibited the growth of the human carcinoma cell lines KB, HeLa, DU-145, Hep 3B, and the leukemia cell line HL-60, and showed less cytotoxicity than adriamycin againsta normal cell line (WISH). All four compounds inhibited the viability of S-180 tumor cells in an in vitro assay and an in vivo S-180 tumor-bearing ICR mice model. Oenothein B demonstrated the greatest cytotoxicity (IC50 = 11.4 mu g/ml) against S-180 tumor cells in culture, while cuphiin D-1 resulted in the greatest increase in survival on S-180 tumor-bearing mice (%ILS = 84.1%). Our findings suggest that the antitumor effects of these compounds are not only related to their cytotoxicity on carcinoma cell lines, but also depended on a host-mediated mechanism; they may therefore have potential for antitumor applications. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 04:16:40