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Titolo:
Acute interactions between L-DOPA and the neurotoxic effects of 1-methyl-4-phenylpyridinium or 6-hydroxydopamine in mice
Autore:
Cleren, C; Vilpoux, C; Dourmap, N; Bonnet, JJ; Costentin, J;
Indirizzi:
CNRS,nceRESA 6036, Unite Neuropsychopharmacol Expt, F-76800 St Etienne, Fra CNRS St Etienne France F-76800 hopharmacol Expt, F-76800 St Etienne, Fra
Titolo Testata:
BRAIN RESEARCH
fascicolo: 2, volume: 830, anno: 1999,
pagine: 314 - 319
SICI:
0006-8993(19990605)830:2<314:AIBLAT>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
PARKINSONS-DISEASE; CHRONIC LEVODOPA; IN-VIVO; NEURONS; TOXICITY; MPTP; 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; MECHANISM; BINDING; MOUSE;
Keywords:
6-hydroxydopamine; 1-methyl-4-phenylpyridinium; L-DOPA; neurotoxicity; hypothalamic noradrenergic neuron; nigro-striatal dopaminergic neuron; vesicular monoamine transporter type 2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Costentin, J CNRS,adrillet,Ave, Unite Neuropsychopharmacol Expt, IFRMP No 23,Site Univ M CNRS IFRMP No 23,Site Univ Madrillet,Ave Univ St Etienne France F-76800
Citazione:
C. Cleren et al., "Acute interactions between L-DOPA and the neurotoxic effects of 1-methyl-4-phenylpyridinium or 6-hydroxydopamine in mice", BRAIN RES, 830(2), 1999, pp. 314-319

Abstract

We have compared the effects of an i.p. pretreatment with L-DOPA (200 mg/kg) associated with benserazide (25 mg/kg) on neurotoxic effects of either 6-hydroxydopamine (6-OHDA) (50 mu g, 10 mu l per mouse) or 1-methyl-4-phenylpyridinium (MPP+) (17.5 mu g, 10 mu l per mouse). The striatal dopamine (DA) content, the vesicular monoamine transporter (VMAT2) density, as well as the hypothalamic norepinephrine (NE) content were measured 8 days after treatments. The L-DOPA-benserazide pretreatment worsened by 65% the 6-OHDA-induced depletion in striatal DA. On the contrary, it reduced by 42% the MPP+-induced depletion in striatal DA and by 54% the MPP+-induced decrease in VMAT2 density. It was noticed that the L-DOPA-benserazide pretreatment did not modify the marked decrease in hypothalamic NE content induced by 6-OHDA. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 19:07:40