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Titolo:
The effects of naltrexone maintenance on the response to yohimbine in healthy volunteers
Autore:
Rosen, MI; Kosten, TR; Kreek, MJ;
Indirizzi:
Yale Univ, Sch Med, VA Connecticut Healthcare Syst, Psychiat Serv, W Haven, Yale Univ W Haven CT USA 06516 t Healthcare Syst, Psychiat Serv, W Haven, Rockefeller Univ, New York, NY 10021 USA Rockefeller Univ New York NY USA10021 eller Univ, New York, NY 10021 USA
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 12, volume: 45, anno: 1999,
pagine: 1636 - 1645
SICI:
0006-3223(19990615)45:12<1636:TEONMO>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-DOSE NALOXONE; RECEPTOR-BINDING; NORADRENERGIC FUNCTION; NORADRENALINE RELEASE; MORPHINE WITHDRAWAL; LOCUS COERULEUS; STRESS-DISORDER; PANIC DISORDER; ANTAGONIST; BRAIN;
Keywords:
naltrexone; yohimbine; noradrenergic; stress; cortisol; locus coeruleus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Rosen, MI Yale Univ, Sch Med, VA Connecticut Healthcare Syst, Psychiat Serv, 116A,950 Yale Univ 116A,950 Campbell Ave W Haven CT USA 06516 v, 116A,950
Citazione:
M.I. Rosen et al., "The effects of naltrexone maintenance on the response to yohimbine in healthy volunteers", BIOL PSYCHI, 45(12), 1999, pp. 1636-1645

Abstract

Background: Preclinical research suggests that opiate antagonists may alter stress responsiveness. This study describes the effect of pretreatment with the opioid antagonist naltrexone on the response to a noradrenergic stressor, the alpha-2-receptor-antagonist, yohimbine, in healthy subjects. The current study was designed to compare the change in responses to yohimbine after 2 weeks of treatment with naltrexone to the response after at least 2weeks of treatment with placebo. Methods: After a week of placebo naltrexone treatment, ten subjects were randomized into a double-blind crossover to placebo or active naltrexone (50mg po daily) on weeks 2 to 4 and the converse condition for weeks 5 to 7. Subjects received challenges in a random, fixed sequence with placebo and active yohimbine (IV, 0.2 mg/kg) on weeks I, 4, and 7. The active-active combination generally had the strongest drug effects. Results: There were statistically significant (p < .05) interactions of naltrexone condition X yohimbine condition for subject ratings of "nervous," "not liking the drug effect " "talkative, " and "urge to urinate, " and a trend (p < .10) for cortisol levels,Conclusions: The results suggest that clinically used naltrexone doses alter sensitivity to yohimbine, (C) 1999 Society of Biological Psychiatry.

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Documento generato il 06/04/20 alle ore 22:55:50