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Titolo:
A structured, dynamic model for animal cell culture: application to baculovirus insect cell systems
Autore:
Sanderson, CS; Barford, JP; Barton, GW; Wong, TKK; Reid, S;
Indirizzi:
Hong Kong Univ Sci & Technol, Dept Chem Engn, Kowloon, Hong Kong Hong KongUniv Sci & Technol Kowloon Hong Kong Engn, Kowloon, Hong Kong Univ Sydney, Dept Chem Engn, Sydney, NSW 2006, Australia Univ Sydney Sydney NSW Australia 2006 m Engn, Sydney, NSW 2006, Australia Univ Queensland, Dept Chem Engn, St Lucia, Qld 4072, Australia Univ Queensland St Lucia Qld Australia 4072 St Lucia, Qld 4072, Australia
Titolo Testata:
BIOCHEMICAL ENGINEERING JOURNAL
fascicolo: 3, volume: 3, anno: 1999,
pagine: 219 - 229
SICI:
1369-703X(199906)3:3<219:ASDMFA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECOMBINANT BACULOVIRUS; SUSPENSION-CULTURE; INFECTION; EXPRESSION; VECTOR; PROTEINS; GROWTH;
Keywords:
insect cell culture; dynamic modelling; dynamic simulation; biokinetics; metabolite over production; beta-galactosidase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Barford, JP Hong Kong Univ Sci & Technol, Dept Chem Engn, Kowloon, Hong Kong Hong Kong Univ Sci & Technol Kowloon Hong Kong n, Hong Kong
Citazione:
C.S. Sanderson et al., "A structured, dynamic model for animal cell culture: application to baculovirus insect cell systems", BIOCH ENG J, 3(3), 1999, pp. 219-229

Abstract

Viral infection can have significant effects on the behaviour of cell cultures and the interaction of baculoviruses with insect cells is currently ofparticular interest. This paper examines a number of existing mathematicalmodels for this phenomenon and describes the development of an extension to a structured model for cellular metabolism. This extension is capable of describing the effects of multiple and secondary infection, the actions of defective interfering particles and the release of viral products through cell lysis, as well as considering the metabolic effects of infection. The basic model is applied to uninfected SF9 cultures, demonstrating that, with a suitable adjustment of its parameters, a model that successfully described hybridoma cells can also be used for insect cells. The extended model is applied to an infected culture and describes the infection process well. (C) 1999 Elsevier Science S.A. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 16:27:51