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Titolo:
Antiproliferative and GH-inhibitory activity of chimeric peptides consisting of GHRP-6 and somatostatin
Autore:
Dasgupta, P; Singh, AT; Mukherjee, R;
Indirizzi:
Natl Inst Immunol, Neuroimmunol Lab, New Delhi 110067, India Natl Inst Immunol New Delhi India 110067 ol Lab, New Delhi 110067, India
Titolo Testata:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
fascicolo: 2, volume: 259, anno: 1999,
pagine: 379 - 384
SICI:
0006-291X(19990607)259:2<379:AAGAOC>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
HORMONE-RELEASING PEPTIDE; ANTERIOR-PITUITARY-CELLS; GROWTH-HORMONE; ANALOG RC-160; IN-VITRO; RECEPTOR; ADENOMAS; TUMORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Mukherjee, R Dabur Res Fdn, 22,Site 4, Ghaziabad 201010, Uttar Pradesh, India Dabur Res Fdn 22,Site 4 Ghaziabad Uttar Pradesh India 201010
Citazione:
P. Dasgupta et al., "Antiproliferative and GH-inhibitory activity of chimeric peptides consisting of GHRP-6 and somatostatin", BIOC BIOP R, 259(2), 1999, pp. 379-384

Abstract

Chimeric peptides consisting of growth hormone releasing peptide (GHRP-6) linked to somatostatin (6-11) via an amide bond to provide the effector parts of both the peptides were synthesized. The anti-proliferative, cytotoxic, and GH-inhibitory activities of these chimeric peptides were determined in vitro in the rat pituitary adenoma cell line GH3. One of the chimeric peptides, GSD, exhibited significantly greater (p < 0.001) anti-neoplastic andGH-inhibitory activity, as compared to RC-160, The hybrid peptides displayed high affinity binding to somatostatin receptors on GH3 cells, The bioactivity of GSD was found to be mediated by the stimulation of tyrosine phosphatase, involving a cGMP-dependent pathway, through pertusis toxin-sensitiveG-proteins. Such potent GH-inhibitory chimeric peptides may be of potential importance in the therapy of acromegaly, as well as provide novel tools to study the regulation of GH secretion by GHRP and somatostatin. (C) 1999 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 01:25:03