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Titolo:
Regional ischemia increases sensitivity of left ventricular relaxation to volume in pigs
Autore:
Solomon, SB; Glantz, SA;
Indirizzi:
UnivCAalif San Francisco, Div Cardiol, Inst Cardiovasc Res, San Francisco,Univ Calif San Francisco San Francisco CA USA 94143 c Res, San Francisco, Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA Univ CalifSan Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
fascicolo: 6, volume: 45, anno: 1999,
pagine: H1994 - H2005
SICI:
0363-6135(199906)45:6<H1994:RIISOL>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
CANINE LEFT-VENTRICLE; SYSTOLIC PRESSURE-VOLUME; BRIEF CORONARY-OCCLUSION; PACING-INDUCED ISCHEMIA; CAT PAPILLARY-MUSCLE; DIASTOLIC FUNCTION; 2-DIMENSIONAL ECHOCARDIOGRAPHY; MYOCARDIAL RELAXATION; CONDUCTANCE CATHETER; CALCIUM TRANSIENTS;
Keywords:
diastolic function; myocardial stretch; preload; cardiac mechanics;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Solomon, SB Univrancisco,n Francisco, Div Cardiol, Inst Cardiovasc Res, Box 0130, San F Univ Calif San Francisco Box 0130 San Francisco CA USA 94143 F
Citazione:
S.B. Solomon e S.A. Glantz, "Regional ischemia increases sensitivity of left ventricular relaxation to volume in pigs", AM J P-HEAR, 45(6), 1999, pp. H1994-H2005

Abstract

Regional ischemia impairs early diastolic filling due, in part, to changesin left ventricular relaxation. This study uses open-chest pigs instrumented with high-fidelity pressure transducers to investigate the effect of regional ischemia on the active component of relaxation independent of the passive effects of filling and the effect of left ventricular filling and stretch on the rate, duration, and extent of relaxation. During regional ischemia, active relaxation was impaired in the nonfilling ventricle, with a slower rate of relaxation. Stretching the myocardium as the ventricle fills slows the rate of relaxation more during regional ischemia than during normal perfusion, reflecting an increased sensitivity to stretch due to filling and an increased dependence of relaxation on volume. The duration of relaxation depends on the effect of regional ischemia on the end-diastolic pressure-volume relation. Stronger baseline contractile function results in an upward shift in the end-diastolic pressure-volume relation during regional ischemia and no net effect on the duration of relaxation. If this curve is shifted upward, the duration of relaxation shortens. All these effects combine to reduce the atrioventricular pressure gradient and left: ventricular filling during regional ischemia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 06:23:20