Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
In-vitro anti-proliferative effects of some anti-tumour drugs on feline mammary tumour cell lines
Autore:
Muleya, JS; Nakaichi, M; Taura, Y; Yamaguchi, R; Nakama, S;
Indirizzi:
YamaguchiJapan, United Grad Sch Vet Sci, Dept Vet Surg, Yamaguchi 7538515,Yamaguchi Univ Yamaguchi Japan 7538515 Dept Vet Surg, Yamaguchi 7538515, Yamaguchi Univ, United Grad Sch Vet Sci, Vet Hosp, Yamaguchi 7538515, Japan Yamaguchi Univ Yamaguchi Japan 7538515 et Hosp, Yamaguchi 7538515, Japan Miyazaki Univ, Dept Vet Pathol, Miyazaki 8892192, Japan Miyazaki Univ Miyazaki Japan 8892192 Vet Pathol, Miyazaki 8892192, Japan
Titolo Testata:
RESEARCH IN VETERINARY SCIENCE
fascicolo: 3, volume: 66, anno: 1999,
pagine: 169 - 174
SICI:
0034-5288(199906)66:3<169:IAEOSA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-BREAST-CANCER; MALIGNANT-TUMORS; CATS; CARCINOMAS; TOXICITY; GROWTH; MITOXANTRONE; DOXORUBICIN; SENSITIVITY; INTERFERON;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Nakaichi, M Yamaguchiaguchi United Grad Sch Vet Sci, Dept Vet Surg, Yoshida 1677-1, Yam Yamaguchi Univ Yoshida 1677-1 Yamaguchi Japan 7538515 -1, Yam
Citazione:
J.S. Muleya et al., "In-vitro anti-proliferative effects of some anti-tumour drugs on feline mammary tumour cell lines", RES VET SCI, 66(3), 1999, pp. 169-174

Abstract

Six anti-tumour drugs namely; doxorubicin, mitoxantrone, vincristine, cisplatin, recombinant human tumour necrosis factor alpha (rh-TNF alpha) and recombinant feline interferon gamma (rf-IFN gamma) were singly evaluated for their anti-proliferative effects on two feline cell lines (FRM and NAG) derived from mammary adenocarcinoma and grown as monolayers. We obtained concentration response curves that enabled the determination of the concentration inhibiting growth by 50 per cent (IC50) for the chemotherapeutic agents with VCR exhibiting exponential-plateau curves. Differences in anti-proliferative effects of drugs to a given cell line and between the cell lines werealso observed. NAC cells were relatively more resistant compared with FRM cells. The relative resistances for NAC cells were 4.19, 12.96, 0.05 and 2.10-fold to doxorubicin, mitoxantrone, vincristine and cisplatin, respectively. FRM cells were more resistant to VCR at lower concentrations compared with NAC cells. The cells appeared, at least in vitro, least sensitive to rh-TNFa and rf-IFN gamma. rh-TNF alpha and rf-IFN gamma were 23 and 29 per cent inhibitory to FRM cells and only 13 and 15 per cent inhibitory to NAC cells, respectively.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 07:10:03