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Titolo:
Enhancement of sustained attention performance by the nicotinic acetylcholine receptor agonist ABT-418 in intact but not basal forebrain-lesioned rats
Autore:
McGaughy, J; Decker, MW; Sarter, M;
Indirizzi:
Ohio State Univ, Dept Psychol, Columbus, OH 43210 USA Ohio State Univ Columbus OH USA 43210 ept Psychol, Columbus, OH 43210 USA Abbott Labs, Div Pharmaceut Prod, Abbott Pk, IL USA Abbott Labs Abbott PkIL USA abs, Div Pharmaceut Prod, Abbott Pk, IL USA
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 2, volume: 144, anno: 1999,
pagine: 175 - 182
Fonte:
ISI
Lingua:
ENG
Soggetto:
BEHAVIORAL VIGILANCE; CORTICAL ACETYLCHOLINE; CHOLINERGIC SYSTEMS; COGNITIVE FUNCTIONS; ALZHEIMERS-DISEASE; TASK; MEMORY; METHYLPHENIDATE; PHYSOSTIGMINE; PHARMACOLOGY;
Keywords:
nicotinic acetylcholine receptor; ABT-418; methylphenidate; basal forebrain; 192 IgG-saporin; sustained attention; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Sarter, M Ohio State Univ, Dept Psychol, 27 Townshend Hall, Columbus, OH 43210 USA Ohio State Univ 27 Townshend Hall Columbus OH USA 43210 3210 USA
Citazione:
J. McGaughy et al., "Enhancement of sustained attention performance by the nicotinic acetylcholine receptor agonist ABT-418 in intact but not basal forebrain-lesioned rats", PSYCHOPHAR, 144(2), 1999, pp. 175-182

Abstract

Rationale: Loss of telencephalic cholinergic projections has been postulated to contribute significantly to the cognitive decline associated with aging and dementia. Objective: The effects of the nicotinic acetylcholine receptor agonist ABT-418, a potential therapeutic drug for the treatment of theage- and dementia-associated cognitive disorders, were tested in an animalmodel of the cortical cholinergic deafferentation-induced impairments in sustained attention. Methods: Animals were trained in an operant task designed to test sustained attention performance. A partial loss of cortical cholinergic inputs was produced by infusions of 192 IgG-saporin into the basal forebrain. The effects of the systemic administration of ABT-418 (0.04, 0.13, 0.39 mg/kg) and the psychostimulant methylphenidate (0.2, 0.4, 0.8 mg/kg) were assessed. Results: Compared with sham-lesioned animals, this lesion resulted in a decrease in the relative number of hits while the relative number of correct rejections remained unaffected. Administration of ABT-418 significantly improved the relative number of hits. Furthermore, this effectof ABT-418 interacted with the effects of the lesion. Unexpectedly, this interaction was based on a significant enhancement of the performance of sham-lesioned animals while no effects were found in 192 IgG-saporin-lesioned animals. Administration of methylphenidate did not affect performance. Conclusions: While these data do not support the hypothesis that administrationof ABT-418 attenuates the impairments in attentional performance that result from loss of cortical cholinergic inputs, they support previous notions about this drug's ability to enhance cognitive processes in intact subjects.

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Documento generato il 22/01/20 alle ore 19:28:28