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Titolo:
The tracheobronchial tree is abnormal in experimental congenital diaphragmatic hernia
Autore:
Xia, H; Migliazza, L; Diez-Pardo, JA; Tovar, JA;
Indirizzi:
Hosp Infantil Univ La Paz, Dept Surg, E-28046 Madrid, Spain Hosp Infantil Univ La Paz Madrid Spain E-28046 rg, E-28046 Madrid, Spain
Titolo Testata:
PEDIATRIC SURGERY INTERNATIONAL
fascicolo: 3-4, volume: 15, anno: 1999,
pagine: 184 - 187
SICI:
0179-0358(199905)15:3-4<184:TTTIAI>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
FETAL RATS; MALFORMATIONS; HYPOPLASIA; SURVIVAL; REPAIR; DEFECT;
Keywords:
congenital diaphragmatic hernia; associated malformations; nitrofen; tracheobronchial anomalies;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Tovar, JA Hospinnfantil Univ La Paz, Dept Surg, P Castellana 261, E-28046 Madrid, Spa Hosp Infantil Univ La Paz P Castellana 261 Madrid Spain E-28046
Citazione:
H. Xia et al., "The tracheobronchial tree is abnormal in experimental congenital diaphragmatic hernia", PEDIAT SURG, 15(3-4), 1999, pp. 184-187

Abstract

Neonates with congenital diaphragmatic hernia (CDH) have other malformations that contribute to the high mortality. The nitrofen rat model allows experimental study of these anomalies. This study exam; ines whether the tracheobronchial tree is also abnormal in this model. Time-mated rats received 100 mg nitrofen on gestational day 9.5; 90 fetuses were harvested on day 21 (near full term) and dissected. The trachea and bronchi were stained with alcian blue-alizarin red and their anatomy was examined by transilluminationunder a microscope. The findings were compared with those of 11 suitable controls. Control pups had no malformations. Those with CDH (n = 57) had significantly-decreased numbers of tracheal rings in comparison with controls (22.9 +/- 1.9 vs 26 +/- 1.9, P < 0.05) and 40/57 had fragmented rings (0 incontrols). Twelve CDH animals had, in addition, tracheal stenoses of variable severity, sometimes related to vascular rings. Nitrofen fetuses withoutCDH (n = 33) had only short tracheas and 4 had mild stenoses. Nitrofen-exposed fetuses have, in addition to lung hypoplasia and sometimes CDH. severetracheobronchial anomalies that suggest the involvement of pathogenetic mechansims capable of acting on various tissue components. The genetic control of organogenesis is most probably disturbed by the teratogen.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 09:36:32