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Titolo:
Intravenous midazolam for sedation of children undergoing procedures: An analysis of age- and procedure-related factors
Autore:
Karl, HW; Cote, CJ; McCubbin, MM; Kelley, M; Liebelt, E; Kaufman, S; Burkhart, K; Albers, O; Wasserman, O;
Indirizzi:
Childrens Hosp & Med Ctr, Dept Anesthesiol, Seattle, WA 98105 USA Childrens Hosp & Med Ctr Seattle WA USA 98105 siol, Seattle, WA 98105 USA
Titolo Testata:
PEDIATRIC EMERGENCY CARE
fascicolo: 3, volume: 15, anno: 1999,
pagine: 167 - 172
SICI:
0749-5161(199906)15:3<167:IMFSOC>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMALL-BOWEL BIOPSY; CONSCIOUS SEDATION; ORAL MIDAZOLAM; PREMEDICATION; FENTANYL; SAFETY;
Keywords:
midazolam; sedation of infants; children; adverse events; pulse oximetry; opioids; fentanyl; meperidine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Karl, HW Childrens1,osp & Med Ctr, Dept Anesthesiol, 4800 Sand Point Way NE,POB C537 Childrens Hosp & Med Ctr 4800 Sand Point Way NE,POB C5371 Seattle WA USA 98105
Citazione:
H.W. Karl et al., "Intravenous midazolam for sedation of children undergoing procedures: An analysis of age- and procedure-related factors", PEDIAT EMER, 15(3), 1999, pp. 167-172

Abstract

Objective: This study was performed to determine the doses of midazolam used for sedation during procedures in children, and the frequency of adverseevents. Methods: We performed a retrospective analysis of data collected for a prospective study of flumazenil in children who had received midazolam for a procedure (n = 91, 1-17 years). Results: Practitioners used a wide range of total midazolam doses (0.03-0.6 mg/kg); mean doses ranged from 0.09 +/- 0.06 mg/kg in adolescents to 0.26+/- 0.13 mg/kg in toddlers (P < 0.001). Opioids were also used in 84% of patients. Twenty-six percent of children with normal lungs, most of whom hadreceived relatively high opioid doses, developed decreased oxygen saturation las low as 65%) after sedation. Other adverse events included airway obstruction (n = 3) and vomiting (n = 1). Conclusions: The frequent choice of midazolam, usually combined with an opioid, indicates its nide acceptance. Midazolam doses were inversely relatedto age. The presence of vomiting, airway obstruction, and decreased oxygensaturation underlines the importance of appropriate personnel, equipment, and monitors during sedation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 20:44:52