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Titolo:
The 5-HT1A receptor agonist flesinoxan increases aversion in a model of panic-like anxiety in rats
Autore:
Jenck, F; Martin, JR; Moreau, JL;
Indirizzi:
Preclin CNS Res, ROCHE Pharma Div, CH-4070 Basel, Switzerland Preclin CNS Res Basel Switzerland CH-4070 iv, CH-4070 Basel, Switzerland
Titolo Testata:
JOURNAL OF PSYCHOPHARMACOLOGY
fascicolo: 2, volume: 13, anno: 1999,
pagine: 166 - 170
SICI:
0269-8811(199906)13:2<166:T5RAFI>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELEVATED X-MAZE; PERIAQUEDUCTAL GRAY; YOHIMBINE; LIGANDS; MONKEYS; DRUGS;
Keywords:
animal model; anxiety; brain stimulation; 5-HT1A; panic; periaqueductal grey;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Jenck, F F Hoffmann La Roche & Co Ltd, PRPND, B72-R148, CH-4070 Basel, Switzerland F Hoffmann La Roche & Co Ltd B72-R148 Basel Switzerland CH-4070
Citazione:
F. Jenck et al., "The 5-HT1A receptor agonist flesinoxan increases aversion in a model of panic-like anxiety in rats", J PSYCHOPH, 13(2), 1999, pp. 166-170

Abstract

Acute systemic administration of the selective serotonin (5-HT)(1A) receptor full agonist flesinoxan enhanced the sensitivity of rats to the panic-like aversion elicited by local stimulation of the dorsolateral periaqueductal grey (dPAG). This experimental paradigm in rats has previously been validated as a simulation of acute anxiety with particular relevance to panic disorder. The dose-dependent decrease in threshold for acute fear responses recorded in rats following intraperitoneal administration of flesinoxan (1-10mg/kg) was similar to that induced by the panic precipitating agent yohimbine and opposite to the threshold increase induced by the antipanic drug alprazolam. The proaversive effect of flesinoxan observed in rats is consistent with the reported aggravation of the condition of panic patients following oral flesinoxan treatment. Thus, the model adequately detects drug-induced panicogenic-like properties. Data suggest that selective activation of 5-HT1A receptors (pre- and/or post-synaptic in brain and/or periphery) following systemic administration of 5-HT1A receptor full agonists exacerbates aversion in animals or patients with panic anxiety; activation of these receptor subtypes may probably mediate the panicogenic action reported under certain circumstances with non-selective 5-HT mimetics.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:43:10