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Titolo:
Attenuation of some subjective effects of amphetamine following tyrosine depletion
Autore:
McTavish, SFB; McPherson, MH; Sharp, T; Cowen, PJ;
Indirizzi:
Univ Oxford, Warneford Hosp, Dept Psychiat, Oxford OX3 7JX, England Univ Oxford Oxford England OX3 7JX ept Psychiat, Oxford OX3 7JX, England Univ Oxford, Radcliffe Infirm, Dept Clin Pharmacol, Oxford OX2 6HE, England Univ Oxford Oxford England OX2 6HE in Pharmacol, Oxford OX2 6HE, England
Titolo Testata:
JOURNAL OF PSYCHOPHARMACOLOGY
fascicolo: 2, volume: 13, anno: 1999,
pagine: 144 - 147
SICI:
0269-8811(199906)13:2<144:AOSSEO>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRYPTOPHAN DEPLETION; PLASMA TRYPTOPHAN; SEROTONIN; BRAIN; PHARMACOLOGY;
Keywords:
d-amphetamine; catecholamines; healthy volunteers; subjective effects; tyrosine depletion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: McTavish, SFB Univ Oxford, Warneford Hosp, Dept Psychiat, Oxford OX3 7JX, England Univ Oxford Oxford England OX3 7JX Oxford OX3 7JX, England
Citazione:
S.F.B. McTavish et al., "Attenuation of some subjective effects of amphetamine following tyrosine depletion", J PSYCHOPH, 13(2), 1999, pp. 144-147

Abstract

Fifteen healthy volunteers received d-amphetamine (20 mg orally) 2 h afteringesting either a nutritionally balanced amino acid mixture or one lacking the catecholamine precursors, tyrosine and phenylalanine (TYR-free). Plasma tyrosine levels were significantly lowered in subjects who received the TYR-free mixture but mean plasma amphetamine levels were higher. Despite this, the TYR-free mixture appeared to decrease the subjective psychostimulant effects of amphetamine, as determined by visual analogue scales. In contrast, the TYR-free mixture failed to lower the subjective anorectic effect of amphetamine. These findings are consistent with animal experimental studies indicating that tyrosine depletion attenuates the release of dopamine produced by amphetamine but not the release of noradrenaline.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 22:00:38