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Titolo:
Quantification of myocardial blood flow using N-13-ammonia and PET: Comparison of tracer models
Autore:
Choi, Y; Huang, SC; Hawkins, RA; Kim, JY; Kim, BT; Hoh, CK; Chen, K; Phelps, ME; Schelbert, HR;
Indirizzi:
Sung Kyun Kwan Univ, Sch Med, Dept Nucl Med, Samsung Med Ctr, Seoul 135230, Sung Kyun Kwan Univ Seoul South Korea 135230 sung Med Ctr, Seoul 135230, Univrmacol,Los Angeles, Sch Med, Div Nucl Med & Biophys, Dept Mol & Med Pha Univ Calif Los Angeles Los Angeles CA USA & Biophys, Dept Mol & Med Pha
Titolo Testata:
JOURNAL OF NUCLEAR MEDICINE
fascicolo: 6, volume: 40, anno: 1999,
pagine: 1045 - 1055
SICI:
0161-5505(199906)40:6<1045:QOMBFU>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION TOMOGRAPHY; N-13 AMMONIA; CARDIAC PET; VALIDATION; NITROGEN-13-AMMONIA; STRATEGY; DISEASE; IMAGES;
Keywords:
myocardial blood flow; N-13-ammonia; PET; tracer kinetic methods;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Kim, BT Sung,Kyun Kwan Univ, Sch Med, Dept Nucl Med, Samsung Med Ctr, 50 Ilwon Dong Sung Kyun Kwan Univ 50 Ilwon Dong Seoul South Korea 135230 n Dong
Citazione:
Y. Choi et al., "Quantification of myocardial blood flow using N-13-ammonia and PET: Comparison of tracer models", J NUCL MED, 40(6), 1999, pp. 1045-1055

Abstract

Several tracer kinetic methods have been proposed for quantification of regional myocardia[ blood flow (MBF) with N-13-ammonia and PET. Merits and limitations specific to each approach, however, generally are not clear, because they have not been evaluated in the same experimental environment. Therefore, we compared six different commonly used methods (11 modifications) to characterize the accuracy of each approach. The methods included the two-parameter model (method 1), the modified two-parameter model (method 2), the four-parameter model (method 3), the graphical analysis (method 4), the first-pass extraction method (method 5) and the dose uptake index (DUI; method 6). Methods: Eleven studies in four dogs, 16 studies in eight healthy human volunteers and 14 studies in seven patients were performed using N-13-ammonia and PET. MBF in dogs was varied with dipyridamole and coronary occlusions and was measured independently and simultaneously with microspheres. Volunteers and patients were studied at baseline and after dipyridamole. MBF and DUI were estimated using a time-activity curve (Q(i)[t]) derived fromdynamic images and regions of interest (ROIs) and using the six methods. DUI was defined as Q(i)(t = 2 min) x weight/dose. Results: MBF estimated by methods 1-5 correlated well with microsphere MBF in dogs. MBF estimates by method 1 correlated well with those by methods 2, 4 and 5 and to a lesser degree with those by method 3 in both dog and human studies. DUI correlated poorly with MBF by microspheres and by methods 1-5 in both dog and human studies. MBF estimates by method 3 showed larger dispersion (SD/mean flow) and higher sensitivity to metabolites correction in arterial blood than thoseby methods 1, 2, 4 and 5. Conclusion: MBF can be measured accurately usingN-13-ammonia PET and tracer kinetic methods. DUI is a poor indicator of MBF values. The results indicate that preference should be given to the two-parameter model, incorporating geometrical ROI representation (method 2) among the compartment models, and to the graphical analysis (method 4) among the noncompartmental approaches.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/02/20 alle ore 13:35:36