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Titolo:
Technetium HMPAO SPECT study in dementia with Lewy bodies, Alzheimer's disease and idiopathic Parkinson's disease
Autore:
Defebvre, LJP; Leduc, V; Duhamel, A; Lecouffe, P; Pasquier, F; Lamy-Lhullier, C; Steinling, M; Destee, A;
Indirizzi:
Nucl Med & Memory Ctr, Dept Neurol A, Lille, France Nucl Med & Memory CtrLille France ry Ctr, Dept Neurol A, Lille, France Nucl Med & Memory Ctr, Dept Med Informat, Lille, France Nucl Med & Memory Ctr Lille France tr, Dept Med Informat, Lille, France
Titolo Testata:
JOURNAL OF NUCLEAR MEDICINE
fascicolo: 6, volume: 40, anno: 1999,
pagine: 956 - 962
SICI:
0161-5505(199906)40:6<956:THSSID>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHOTON-EMISSION TOMOGRAPHY; CEREBRAL GLUCOSE-UTILIZATION; BODY-DISEASE; CLINICAL-DIAGNOSIS; BLOOD-FLOW; FEATURES; TC-99M-HMPAO; CRITERIA; VARIANT;
Keywords:
dementia with Lewy bodies; Alzheimer's disease; Parkinson's disease; SPECT; Tc-99m-hexamethyl propyleneamine oxime;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Defebvre, LJP CHRU,ance Roger Salengro, Serv Neurol & Pathol Mouvement, F-59037 Lille, Fr CHRU Lille France F-59037 hol Mouvement, F-59037 Lille, Fr
Citazione:
L.J.P. Defebvre et al., "Technetium HMPAO SPECT study in dementia with Lewy bodies, Alzheimer's disease and idiopathic Parkinson's disease", J NUCL MED, 40(6), 1999, pp. 956-962

Abstract

The aim of this, study was to compare the regional cerebral blood flow measurements studied by SPECT in dementia with Lewy bodies (DLB) and Alzheimer's disease (AD) to determine the contribution of SPECT to the differential diagnosis of these two diseases. Methods: SPECT analysis with Tc-99m-hexamethyl propyleneamine oxime (HMPAO) was performed in 20 patients with probable DLB, 20 patients with probable AD and 20 patients with idiopathic Parkinson's disease (IPD). Ten pairs of regions of interest were analyzed. Tracer uptake was expressed as a corticocerebellar activity ratio. Results: Compared with IPD, in the DLB group there was a global decrease of HMPAO uptake in cortical regions of interest except in the posterior frontal and occipital regions; in the AP group there was limited left temporal and parietal hypoperfusion. In the DLB group, frontal HMPAO uptake was significantly lower than in the AD group. Two predictive scores were established by a factorialdiscriminant analysis from six left Cortical indices (medial frontal, lateral frontal, posterior frontal, temporoparietal, parietal and parietooccipital) and the Mini-Mental State Examination,which correctly classified 53 of60 patients (88%) (DLB, 18 of 20; AD, 16 of 20; IPD, 19 of 20). Conclusion: These findings indicate the presence of diffuse cortical abnormalities inLB and suggest that SPECT may be useful in discriminating in vivo DLB fromAD, revealing mainly frontal hypoperfusion in the former group. We estimate that SPECT study increases the possibility of separating DLB and AD because both disorders share different patterns of cerebral blood flow abnormality.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/08/20 alle ore 07:55:58