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Titolo:
Altered serotonin innervation patterns in the forebrain of monkeys treatedwith (+/--)3,4-methylenedioxymethamphetamine seven years previously: Factors influencing abnormal recovery
Autore:
Hatzidimitriou, G; McCann, UD; Ricaurte, GA;
Indirizzi:
Johns Hopkins Med Inst, Dept Neurol, Baltimore, MD 21224 USA Johns HopkinsMed Inst Baltimore MD USA 21224 ol, Baltimore, MD 21224 USA NIMH, Unit Anxiety Disorders, Biol Psychiat Branch, Bethesda, MD 20892 USANIMH Bethesda MD USA 20892 , Biol Psychiat Branch, Bethesda, MD 20892 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 12, volume: 19, anno: 1999,
pagine: 5096 - 5107
SICI:
0270-6474(19990615)19:12<5096:ASIPIT>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXHIBIT DIFFERENTIAL VULNERABILITY; RAT-BRAIN; AXON TERMINALS; MDMA ECSTASY; (+/-)3,4-METHYLENEDIOXYMETHAMPHETAMINE MDMA; METHYLENEDIOXYMETHAMPHETAMINE MDMA; RADIOLIGAND BINDING; NONHUMAN-PRIMATES; CEREBRAL-CORTEX; RHESUS-MONKEYS;
Keywords:
amphetamines; methylenedioxymethamphetamine; serotonin; neurotoxicity; regeneration; 5-HT axon;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Ricaurte, GA Johns,Hopkins Med Inst, Dept Neurol, 5501 Hopkins Bayview Circle,Room 5B71E Johns Hopkins Med Inst 5501 Hopkins Bayview Circle,Room 5B71E Baltimore MD USA 21224
Citazione:
G. Hatzidimitriou et al., "Altered serotonin innervation patterns in the forebrain of monkeys treatedwith (+/--)3,4-methylenedioxymethamphetamine seven years previously: Factors influencing abnormal recovery", J NEUROSC, 19(12), 1999, pp. 5096-5107

Abstract

The recreational drug (+/-)3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") is a potent and selective brain serotonin (5-HT) neurotoxin in animalsand, possibly, in humans. The purpose of the present study was to determine whether brain 5-HT deficits persist in squirrel monkeys beyond the 18-month period studied previously and to identify factors that influence recovery of injured 5-HT axons. Seven years after treatment, abnormal brain 5-HT innervation patterns were still evident in MDMA-treated monkeys, although 5-HT deficits in some regions were less severe than those observed at 18 months. No loss of 5-HT nerve cell bodies in the rostral raphe nuclei was found, indicating that abnormal innervation patterns in MDMA-treated monkeys arenot the result of loss of a particular 5-HT nerve cell group. Factors thatinfluence recovery of 5-HT axons after MDMA injury are (1) the distance ofthe affected axon terminal field from the rostral raphe nuclei, (2) the degree of initial 5-HT axonal injury, and possibly (3) the proximity of damaged 5-HT axons to myelinated fiber tracts. Additional studies are needed to better understand these and other factors that influence the response of primate 5-HT neurons to MDMA injury and to determine whether the present findings generalize to humans who use MDMA for recreational purposes.

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Documento generato il 04/04/20 alle ore 15:33:35