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Titolo:
Synthesis of [F-18] SR144385: A selective radioligand for positron emission tomographic studies of brain cannabinoid receptors
Autore:
Mathews, WB; Ravert, HT; Musachio, JL; Frank, RA; Rinaldi-Carmona, M; Barth, F; Dannals, RF;
Indirizzi:
Johns Hopkins Univ, Dept Radiol, Baltimore, MD 21287 USA Johns Hopkins Univ Baltimore MD USA 21287 Radiol, Baltimore, MD 21287 USA Sanofi Pharmaceut, Malvern, PA 19355 USA Sanofi Pharmaceut Malvern PA USA19355 Pharmaceut, Malvern, PA 19355 USA Sanofi Rech, Montpellier 04, France Sanofi Rech Montpellier France 04Sanofi Rech, Montpellier 04, France
Titolo Testata:
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
fascicolo: 6, volume: 42, anno: 1999,
pagine: 589 - 596
SICI:
0362-4803(199906)42:6<589:SO[SAS>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPRESSION; ANTAGONIST; MARIJUANA; BINDS;
Keywords:
cannabinoid; fluorine-18; radiotracer; positron emission tomography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Dannals, RF Johns Hopkins Univ, Dept Radiol, Baltimore, MD 21287 USA JohnsHopkins Univ Baltimore MD USA 21287 imore, MD 21287 USA
Citazione:
W.B. Mathews et al., "Synthesis of [F-18] SR144385: A selective radioligand for positron emission tomographic studies of brain cannabinoid receptors", J LABEL C R, 42(6), 1999, pp. 589-596

Abstract

A cannabinoid receptor antagonist, SR144385, has been labeled with fluorine-18. [F-18] SR144385 was synthesized in a multi-step reaction in which fluorine-18 was introduced by nucleophilic halogen displacement on a bromo precursor. The fluorine-18 labeled intermediate was deprotected and coupled with 1-aminopiperidine to give [F-18] SR144385. The time for radiosynthesis, HPLC purification, and formulation was 2 hours from end-of-bombardment. [F-18] SR144385 of high radiochemical purity was obtained at end-of-synthesis with an average (n = 11) specific radioactivity of 1852 mCi/mu mol and an average isolated, non-decay corrected radiochemical yield of 4% from potassium [F-18] fluoride.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 15:12:07