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Titolo:
Technetium-99m radiolabelling of an N-amino-alkyl-benzamide nitrido- and oxo-technetium bis(aminoethanethiol) derivative synthesis and biological results. Potential melanoma tracer agents.
Autore:
Auzeloux, P; Moreau, MF; Papon, J; Bayle, M; Borel, M; Pasqualini, R; Madelmont, JC;
Indirizzi:
INSERM, U484, F-63005 Clermont Ferrand, France INSERM Clermont Ferrand France F-63005 F-63005 Clermont Ferrand, France CIS Bio Int, F-92192 Gif Sur Yvette, France CIS Bio Int Gif Sur Yvette France F-92192 F-92192 Gif Sur Yvette, France
Titolo Testata:
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
fascicolo: 6, volume: 42, anno: 1999,
pagine: 567 - 579
SICI:
0362-4803(199906)42:6<567:TROANN>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMAGING AGENTS; RADIOPHARMACEUTICALS; BIODISTRIBUTION;
Keywords:
Tc-99m; benzamide; bis(aminothiol); melanoma; nitrido-technetium complex; oxo-technetium complex;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Auzeloux, P INSERM, U484, Rue Montalembert ,BP 184, F-63005 Clermont Ferrand, France INSERM Rue Montalembert ,BP 184 Clermont Ferrand France F-63005
Citazione:
P. Auzeloux et al., "Technetium-99m radiolabelling of an N-amino-alkyl-benzamide nitrido- and oxo-technetium bis(aminoethanethiol) derivative synthesis and biological results. Potential melanoma tracer agents.", J LABEL C R, 42(6), 1999, pp. 567-579

Abstract

N-(2-diethylaminoethyl)-4-iodobenzamide has been reported to be an excellent agent for malignant melanoma diagnosis by SPECT. To obtain a Tc-99m analog, we synthesized a new bis(aminothiol) (BAT) derivative. The benzamide function was conjugated onto a nitrogen of the BAT backbone. This ligand was successfully radiolabelled with both nitrido-technetium and oxo-technetium cores. These complexes were purified by HPLC. Tumour uptake was measured inintravenously injected mice bearing the B16 murine melanoma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 05:59:55