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Titolo:
Predominant expression of Fas (CD95) ligand in metastatic melanoma revealed by longitudinal analysis
Autore:
Terheyden, P; Siedel, C; Merkel, A; Kampgen, E; Brocker, EB; Becker, JC;
Indirizzi:
Univ Wurzburg, Dept Dermatol, Sch Med, D-97080 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97080 ch Med, D-97080 Wurzburg, Germany
Titolo Testata:
JOURNAL OF INVESTIGATIVE DERMATOLOGY
fascicolo: 6, volume: 112, anno: 1999,
pagine: 899 - 902
SICI:
0022-202X(199906)112:6<899:PEOF(L>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-LYMPHOCYTES; APOPTOSIS; RECEPTOR; DEATH; CELLS; MECHANISM;
Keywords:
apoptosis; immune escape mechanism; tumor progression;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Becker, JC Univurg,zburg, Dept Dermatol, Sch Med, Josef Schneider Str 2, D-97080 Wurzb Univ Wurzburg Josef Schneider Str 2 Wurzburg Germany D-97080 b
Citazione:
P. Terheyden et al., "Predominant expression of Fas (CD95) ligand in metastatic melanoma revealed by longitudinal analysis", J INVES DER, 112(6), 1999, pp. 899-902

Abstract

The expression of Fas ligand has recently been proposed as a novel tumor escape mechanism for melanoma. To establish the characteristics of Fas ligand expression during the course of melanoma progression we performed a longitudinal study analyzing primary tumors as well as subsequently evolving metastases, In primary melanoma Fas ligand was expressed in two of 20 lesions;this expression was weak and restricted to few parts of the tumors. The Fas ligand positive primary melanomas were rather thick, i.e., 8.5 and 3.8 mm, versus a median of 2.4 mm of the remaining tumors. In contrast, for metastatic melanoma Fas ligand expression was present in six of 11 cases investigated. The metastases of primary tumors displaying Fas ligand maintained its expression, As Fas ligand positive melanoma cells are capable of inducingapoptosis in susceptible cells, e.g., Fas positive tumor infiltrating lymphocytes, we tested for the presence of apoptotic cells in sial by terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling. This analysisrevealed that apoptotic cells were present within the Fas ligand positive tumors. The number of apoptotic cells, however, never exceeded 5% of the total cells. Thus, Fas ligand mediated apoptosis does not seem to be a major immune escape mechanism for melanoma but its expression correlates with thestage of melanoma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 15:07:07