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Titolo:
Poxvirus-encoded serpins do not prevent cytolytic T cell-mediated recoveryfrom primary infections
Autore:
Mullbacher, A; Wallich, R; Moyer, RW; Simon, MM;
Indirizzi:
Australianberra,Univ, John Curtin Sch Med Res, Div Immunol & Cell Biol, Can Australian Natl Univ Canberra ACT Australia 2601 Immunol & Cell Biol, Can Univ Heidelberg, Inst Immunol, Heidelberg, Germany Univ Heidelberg Heidelberg Germany g, Inst Immunol, Heidelberg, Germany Univ Florida, Dept Immunol & Med Microbiol, Gainesville, FL USA Univ Florida Gainesville FL USA nol & Med Microbiol, Gainesville, FL USA Max Planck Inst Immunbiol, D-7800 Freiburg, Germany Max Planck Inst Immunbiol Freiburg Germany D-7800 7800 Freiburg, Germany
Titolo Testata:
JOURNAL OF IMMUNOLOGY
fascicolo: 12, volume: 162, anno: 1999,
pagine: 7315 - 7321
SICI:
0022-1767(19990615)162:12<7315:PSDNPC>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEFICIENT MICE; VACCINIA VIRUS; TARGET-CELLS; IN-VITRO; CYTOTOXICITY; APOPTOSIS; ECTROMELIA; ANTIGEN; LYMPHOCYTES; SPECIFICITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Mullbacher, A Australian Natl Univ, John Curtin Sch Med Res, Div Immunol &Cell Biol, POB Australian Natl Univ POB 334 Canberra ACT Australia 2601 POB
Citazione:
A. Mullbacher et al., "Poxvirus-encoded serpins do not prevent cytolytic T cell-mediated recoveryfrom primary infections", J IMMUNOL, 162(12), 1999, pp. 7315-7321

Abstract

Previous observations that the highly conserved poxvirus-encoded serpins inhibit cytotoxic activities of alloreactive CTL via granule and/or Fas-mediated pathways was taken to indicate their involvement in immune evasion by poxviruses. We now show that interference with Cr-51 release from target cells by ectromelia and cowpoxvirus is limited to alloreactive but not MHC-restricted CTL. The data are in support of the paramount importance of CTL and its effector molecule perforin in the recovery from primary ectromelia virus infection and question the role of serpins in the evasion of poxvirusesfrom killing by CTL, Further analysis of poxvirus interference with targetcell lysis by alloreactive CTL revealed that suppression primarily affectsthe Fas-mediated, and to a lesser extent, the granule exocytosis pathway. Serpin-2 is the main contributor to suppression for both killing pathways, In addition, inhibition of lysis was shown to be both target cell type- andMHC allotype-dependent. We hypothesize that differences in TCR affinities and/or state of activation between alloreactive and MHC-restricted CTL as well as the quality (origin) of target cells are responsible for the observed phenomenon.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 09:50:29