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Titolo:
Corticotropin-releasing hormone signals adversity in both the placenta andthe brain: regulation by glucocorticoids and allostatic overload
Autore:
Schulkin, J;
Indirizzi:
Amer Coll Obstetricians & Gynecologists, Dept Res, Washington, DC 20024 USA Amer Coll Obstetricians & Gynecologists Washington DC USA 20024 20024 USA Georgetown Univ, Dept Physiol & Biophys, Washington, DC USA Georgetown Univ Washington DC USA Physiol & Biophys, Washington, DC USA
Titolo Testata:
JOURNAL OF ENDOCRINOLOGY
fascicolo: 3, volume: 161, anno: 1999,
pagine: 349 - 356
SICI:
0022-0795(199906)161:3<349:CHSAIB>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACOUSTIC STARTLE REFLEX; MESSENGER-RNA; FACTOR CRF; PARAVENTRICULAR NUCLEUS; MATERNAL PLASMA; STRIA TERMINALIS; RAT-BRAIN; BED NUCLEUS; PRETERM DELIVERY; MAJOR DEPRESSION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
107
Recensione:
Indirizzi per estratti:
Indirizzo: Schulkin, J Ameron,ll Obstetricians & Gynecologists, Dept Res, 409 12th StSW, Washingt Amer Coll Obstetricians & Gynecologists 409 12th St SW Washington DC USA 20024
Citazione:
J. Schulkin, "Corticotropin-releasing hormone signals adversity in both the placenta andthe brain: regulation by glucocorticoids and allostatic overload", J ENDOCR, 161(3), 1999, pp. 349-356

Abstract

Glucocorticoids regulate corticotropin-releasing hormone (CRH) gene expression in the placenta and the brain. In both the placenta and two extrahypothalamic sites in the brain (the amygdala and the bed nucleus of the stria terminalis), glucocorticoids elevate CRH gene expression. One functional role of the elevation of CRH by glucocorticoids may be to signal adversity. When CRH is over-expressed in the placenta, it may indicate that the pregnancy is in danger, and preterm labor may result. When CRH is over-expressed inthe brains of animals, they may become more fearful. Both situations possibly reflect allostatic mechanisms and vulnerability to allostatic overload,a condition in which biological tissue may be compromised.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:24:52