Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Clinically significant pharmacokinetic drug interactions between antiepileptic drugs
Autore:
Tanaka, E;
Indirizzi:
Univ Tsukuba, Inst Community Med, Tsukuba, Ibaraki 3058575, Japan Univ Tsukuba Tsukuba Ibaraki Japan 3058575 sukuba, Ibaraki 3058575, Japan
Titolo Testata:
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
fascicolo: 2, volume: 24, anno: 1999,
pagine: 87 - 92
SICI:
0269-4727(199904)24:2<87:CSPDIB>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEBRISOQUINE SPARTEINE METABOLISM; GENETIC-POLYMORPHISM; MEPHENYTOIN HYDROXYLATION; SERUM CONCENTRATIONS; EPILEPTIC PATIENTS; S-MEPHENYTOIN; VALPROIC ACID; CARBAMAZEPINE; PHENYTOIN; CYTOCHROME-P450;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Tanaka, E Univ Tsukuba, Inst Community Med, Tsukuba, Ibaraki 3058575, Japan Univ Tsukuba Tsukuba Ibaraki Japan 3058575 araki 3058575, Japan
Citazione:
E. Tanaka, "Clinically significant pharmacokinetic drug interactions between antiepileptic drugs", J CLIN PH T, 24(2), 1999, pp. 87-92

Abstract

Pharmacokinetic interactions between antiepileptics represent a major potential complication of epilepsy treatment because drug combinations are common. This review discusses pharmacokinetic drug interactions of clinical significance involving antiepileptics and cytochrome P450 (CYP). Most commonlyused antiepileptics are eliminated through hepatic metabolism, catalysed by the enzymes CYP2C9, CYP2C19 and CYP3A4 and uridine diphosphate glucuronosyltransferase (UDGPT). Antiepileptics are associated with a wide range of drug interactions, including hepatic enzyme induction and inhibition. Phenytoin, phenobarbiral, primidone and carbamazepine induce CYP and UDPGT enzymes while valproic acid inhibits them. Avoidance of unnecessary polypharmacy,selection of alternative agents with lower interaction potential and careful dosage adjustments based on serum drug concentration monitoring and clinical observation are the main methods for reducing the risks associated with these interactions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 22:43:01