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Titolo:
Comparison of short-term diet and exercise on insulin action in individuals with abnormal glucose tolerance
Autore:
Arciero, PJ; Vukovich, MD; Holloszy, JO; Racette, SB; Kohrt, WM;
Indirizzi:
Washingtonis,iv, Sch Med, Dept Internal Med, Div Geriatr & Gerontol, St Lou Washington Univ St Louis MO USA 63110 Med, Div Geriatr & Gerontol, St Lou
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 6, volume: 86, anno: 1999,
pagine: 1930 - 1935
SICI:
8750-7587(199906)86:6<1930:COSDAE>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT DIABETES-MELLITUS; RESTING METABOLIC-RATE; GLUT-4 PROTEIN-CONTENT; ABDOMINAL OBESITY; SKELETAL-MUSCLE; WEIGHT-LOSS; CALORIC RESTRICTION; PRACTICAL EQUATION; OLDER MEN; RESISTANCE;
Keywords:
hyperglycemic clamp; low-calorie diet; exercise training; glucose disposal;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Kohrt, WM WashingtonEuclid Sch Med, Dept Internal Med, Div Geriatr & Gerontol, 660 S Washington Univ 660 S Euclid Ave,Campus Box 8113 St Louis MO USA63110
Citazione:
P.J. Arciero et al., "Comparison of short-term diet and exercise on insulin action in individuals with abnormal glucose tolerance", J APP PHYSL, 86(6), 1999, pp. 1930-1935

Abstract

The effects of a 10-day low-calorie diet (LCD; n = 8) or exercise training(ET; n = 8) on insulin secretion and action were compared in obese men (n = 9) and women (n = 7), aged 53 +/- 1 yr, with abnormal glucose tolerance by using a hyperglycemic clamp with superimposed arginine infusion and a high-fat drink. Body mass (LCD, 115 +/- 5 vs. 110 +/- 5 kg; ET, 111 +/- 7 vs. 109 +/- 7 kg; P < 0.01) and fasting plasma glucose (LCD, 115 +/- 10 vs. 99 /- 4 mg/dl; ET, 112 +/- 4 vs. 101 +/- 5 mg/dl, P < 0.01) and insulin (LCD,23.9 +/- 5.6 vs. 15.2 +/- 3.9 mu U/ml; ET, 17.6 +/- 1.9 vs. 13.9 +/- 2.4 mu U/ml; P < 0.05) decreased in both groups. There was a 40% reduction in plasma insulin during hyperglycemia (0-45 min) after LCD (peak: 118 +/- 18 vs. 71 +/- 14 mu U/ml; P < 0.05) and ET (69 +/- 14 vs. 41 +/- 7 mu U/ml; P < 0.05) and trends for reductions during arginine infusion and a high-fat drink. The 56% increase in glucose uptake after ET (4.95 +/- 0.90 vs. 7.74 +/-0.82 mg.min(-1).kg fat-free mass(-1); P < 0.01) was significantly (P < 0.01) greater than the 19% increase (5.72 +/- 1.12 vs. 6.80 +/- 0.94 mg.min(-1).kg fat-free mass(-1); P = not significant) that occurred after LCD. The marked increase in glucose disposal after ET, despite lower insulin levels, suggests that short-term exercise is more effective than diet in enhancing insulin action in individuals with abnormal glucose tolerance.

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Documento generato il 09/07/20 alle ore 00:01:40