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Titolo:
Effect of aging on response to exercise training in humans: skeletal muscle GLUT-4 and insulin sensitivity
Autore:
Cox, JH; Cortright, RN; Dohm, GL; Houmard, JA;
Indirizzi:
E Carolina Univ, Sch Med, Human Performance Lab, Dept Exercise & Sport Sci, E Carolina Univ Greenville NC USA 27858 e Lab, Dept Exercise & Sport Sci, E Carolina Univ, Sch Med, Dept Biochem, Greenville, NC 27858 USA E Carolina Univ Greenville NC USA 27858 Biochem, Greenville, NC 27858 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 6, volume: 86, anno: 1999,
pagine: 2019 - 2025
SICI:
8750-7587(199906)86:6<2019:EOAORT>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
MIDDLE-AGED MEN; GLUCOSE-TRANSPORT; PROTEIN-CONCENTRATION; RATS; TOLERANCE; NIDDM; IMPROVEMENT; METABOLISM; INTENSITY; INVIVO;
Keywords:
insulin action; glucose transport; men; women;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Houmard, JA E Carolina Univ, Sch Med, Human Performance Lab, Dept Exercise& Sport Sci, E Carolina Univ Ward Sports Med Bldg Greenville NC USA 27858 ,
Citazione:
J.H. Cox et al., "Effect of aging on response to exercise training in humans: skeletal muscle GLUT-4 and insulin sensitivity", J APP PHYSL, 86(6), 1999, pp. 2019-2025

Abstract

The purpose of this study was to compare the effects of short-term exercise training on insulin-responsive glucose transporter (GLUT-4) concentrationand insulin sensitivity in young and older individuals. Young and older women [22.4 +/- 0.8 (SE) yr, n = 9; and 60.9 +/- 1.0 yr, n = 10] and men (20.9 +/- 0.9, n = 9; 56.5 +/- 1.9 yr, n = 8), respectively, were studied before and after 7 consecutive days of exercise training (1 h/day, approximate to 75% maximal oxygen uptake). The older groups had more adipose tissue, increased central adiposity, and a lower maximal oxygen uptake. Despite these differences, increases in whole body insulin action (insulin sensitivity index, determined with an intravenous glucose tolerance test and minimal-model analysis) with training were similar regardless of age, in both the womenand men (mean increase of 2.2 +/- 0.3-fold). This was accompanied by similar relative increases in muscle (vastus lateralis) GLUT-4 protein concentration, irrespective of age (mean increase of 3.1 +/- 0.7-fold). Body mass did not change with training in any of the groups. These data suggest that older human skeletal muscle retains the ability to rapidly increase muscle GLUT-4 and improve insulin action with endurance training.

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Documento generato il 27/11/20 alle ore 02:07:33