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Titolo:
Impact of hyperinsulinemia on myosin heavy chain gene regulation
Autore:
Houmard, JA; ONeill, DS; Zheng, DH; Hickey, MS; Dohm, GL;
Indirizzi:
Ele,rolina Univ, Human Performance Lab, Dept Exercise & Sport Sci, Greenvil E Carolina Univ Greenville NC USA 27858 pt Exercise & Sport Sci, Greenvil E Carolina Univ, Dept Biochem, Greenville, NC 27858 USA E Carolina Univ Greenville NC USA 27858 Biochem, Greenville, NC 27858 USA E Carolina Univ, Sch Med, Greenville, NC 27858 USA E Carolina Univ Greenville NC USA 27858 Sch Med, Greenville, NC 27858 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 6, volume: 86, anno: 1999,
pagine: 1828 - 1832
SICI:
8750-7587(199906)86:6<1828:IOHOMH>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
MUSCLE-FIBER COMPOSITION; CHRONIC HEART-FAILURE; SKELETAL-MUSCLE; INSULIN-RESISTANCE; CAPILLARY DENSITY; GLUCOSE-TOLERANCE; ADIPOSE-TISSUE; MESSENGER-RNA; EXPRESSION; NIDDM;
Keywords:
skeletal muscle; insulin resistance; fiber type; messenger; ribonucleic acid;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Houmard, JA Ertsrolina Univ, Human Performance Lab, Dept Exercise & Sport Sci, Ward Spo E Carolina Univ Ward Sports Med Bldg Greenville NC USA 27858 o
Citazione:
J.A. Houmard et al., "Impact of hyperinsulinemia on myosin heavy chain gene regulation", J APP PHYSL, 86(6), 1999, pp. 1828-1832

Abstract

The purpose of this study was to determine whether hyperinsulinemia altersmyosin heavy chain (MHC) gene expression in human skeletal muscle. A biopsy from the vastus lateralis was obtained in young, lean [age 24.6 +/- 1.0 (SE) yr, body fat 11.9 +/- 1.9%, body mass index 26.1 +/- 1.1 kg/m(2); n = 10] men before and after 3 h of hyperinsulinemia (hyperinsulinemic-euglycemic clamp). Muscle was analyzed for mRNA of type I, IIa, and IIx MHC isoforms. Hyperinsulinemia (mean of 1,065.7 +/- 9.8 pmol/l during minutes 20 to 180) did not change (P > 0.05) the mRNA concentration of either the type I MHCor type IIA MHC isoforms. In contrast, type IIX MHC mRNA increased (P < 0.05) with hyperinsulinemia compared with the fasted condition. These data indicate that hyperinsulinemia rapidly increases type IIx MHC mRNA in human skeletal muscle.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 12:55:24