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Titolo:
Effects of phosphodiesterase inhibitors after coronary artery bypass grafting
Autore:
Orime, Y; Shiono, M; Hata, H; Yagi, S; Tsukamoto, S; Okumura, H; Kimura, S; Hata, M; Sezai, A; Obana, M; Sezai, Y;
Indirizzi:
Nihon Univ, Sch Med, Dept Surg 2, Tokyo, Japan Nihon Univ Tokyo JapanNihon Univ, Sch Med, Dept Surg 2, Tokyo, Japan
Titolo Testata:
JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION
fascicolo: 2, volume: 63, anno: 1999,
pagine: 117 - 122
SICI:
0047-1828(199902)63:2<117:EOPIAC>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONGESTIVE HEART-FAILURE; CARDIAC-SURGERY; INTRAVENOUS MILRINONE; AMRINONE;
Keywords:
cardiopulmonary bypass; coronary artery bypass grafting; milrinone; olprinone; phosphodiesterase inhibitor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Orime, Y 30-1 Oyaguchi Kami Machi, Tokyo 173, Japan 30-1 Oyaguchi Kami Machi Tokyo Japan 173 achi, Tokyo 173, Japan
Citazione:
Y. Orime et al., "Effects of phosphodiesterase inhibitors after coronary artery bypass grafting", JPN CIRC J, 63(2), 1999, pp. 117-122

Abstract

The aim of this study was to estimate the postoperative effects of phosphodiesterase (PDE) inhibitors (milrinone and olprinone) after coronary arterybypass grafting (CABG). To prevent hypotension caused by the PDE inhibitors, low dose of catecholamines were used concomitantly. A total of 34 elective CABG cases were tested. In 12 cases, 0.25 mu g kg(-1) min(-1) of milrinone, 3 mu g kg(-1) min(-1) of dobutamine (DOB) and dopamine (DOA) were used concomitantly (Group-M). In another 10 patients, 0.1 mu g kg(-1) min(-1) ofolprinone and the same doses of the catecholamines were infused (Group-O). As a control, the same doses of DOA and DOE only were administered in 12 patients (Group-C). When the pump flow of the cardiopulmonary bypass (CPB) decreased to half, these drugs were given in all groups. Hemodynamics were recorded before CPB, just after the operation, and 3, 6, 12, 24, 48 and 72 hafter the operation. Both milrinone and olprinone increased the cardiac index and decreased systemic vascular resistance to almost the same degree. Olprinone decreased mean aortic and pulmonary artery pressures, and also significantly reduced the preload of both right and left heart compared with milrinone. Significant hypotension was not detected due to the concomitant usage of low-dose catecholamines. This concomitant usage of PDE inhibitors and catecholamines allowed easy weaning from CPB, demonstrating excellent hemodynamics after CABG. Good oxygen demand and supply balance were maintained in peripheral tissue. These results suggest that these new PDE inhibitorsmay be effective not only for weaning from CPB but also for post-cardiotomy cardiogenic shock.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 07:39:00