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Titolo:
Induction of apoptosis in AK-5 cells by rotenone involves participation ofcaspases
Autore:
Khar, A; Ali, AM; Begum, Z; Pardhasaradhi, BVV; Varalakshmi, C;
Indirizzi:
Ctr Cellular & Mol Biol, Hyderabad 500007, Andhra Pradesh, India Ctr Cellular & Mol Biol Hyderabad Andhra Pradesh India 500007 desh, India
Titolo Testata:
INDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS
fascicolo: 2, volume: 36, anno: 1999,
pagine: 77 - 81
SICI:
0301-1208(199904)36:2<77:IOAIAC>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATURAL-KILLER-CELL; TUMOR-CELLS; RAT HISTIOCYTOMA; BCL-2; DEATH; INHIBITORS; EXECUTION; NECROSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Khar, A Ctr Cellular & Mol Biol, Uppal Rd, Hyderabad 500007, Andhra Pradesh, India Ctr Cellular & Mol Biol Uppal Rd Hyderabad Andhra Pradesh India 500007
Citazione:
A. Khar et al., "Induction of apoptosis in AK-5 cells by rotenone involves participation ofcaspases", I J BIOCH B, 36(2), 1999, pp. 77-81

Abstract

AK-5 tumour cells undergo apoptosis after treatment with rotenone an electron transport inhibitor and oligomycin which inhibits mitochondrial ATPases. Apoptotic process involves the induction of caspases 2 and 3, whereas caspase 1 does not seem to be participating in rotenone/oligomycin induced apoptosis. DEVD which is a specific inhibitor of caspase 3, inhibited apoptosis in AK-5 cells. We have also observed a significant lowering of intracellular pH in AK-5 cells which are induced into the apoptotic process by rotenone. These results suggest an important role for mitochondrial electron transport in the induction of apoptosis in AK-5 tumour cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 16:16:37