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Titolo:
Antigen-driven clonal accumulation of peritoneal gamma delta T cells in vivo
Autore:
Kodaira, Y; Ikuta, K; Tanaka, S; Yokomuro, K;
Indirizzi:
Nippon Med Sch, Dept Microbiol, Bunkyo Ku, Tokyo 113, Japan Nippon Med Sch Tokyo Japan 113 pt Microbiol, Bunkyo Ku, Tokyo 113, Japan Nippon Med Sch, Dept Immunol, Bunkyo Ku, Tokyo 113, Japan Nippon Med Sch Tokyo Japan 113 Dept Immunol, Bunkyo Ku, Tokyo 113, Japan Kyoto Univ, Fac Med, Dept Med Chem, Sakyo Ku, Kyoto 606, Japan Kyoto UnivKyoto Japan 606 ed, Dept Med Chem, Sakyo Ku, Kyoto 606, Japan
Titolo Testata:
IMMUNOLOGICAL INVESTIGATIONS
fascicolo: 2-3, volume: 28, anno: 1999,
pagine: 137 - 148
SICI:
0882-0139(1999)28:2-3<137:ACAOPG>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYCOBACTERIUM-TUBERCULOSIS; LISTERIA-MONOCYTOGENES; BACTERIAL-INFECTION; LYMPHOCYTE-T; C57BL/6 MICE; STEM-CELLS; GAMMA/DELTA; SUBSET; DIVERSITY; LIVER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Kodaira, Y Mayo Clin, Dept Surg, Med Sci Bldg 2-66, Rochester, MN 55905 USA Mayo Clin Med Sci Bldg 2-66 Rochester MN USA 55905 MN 55905 USA
Citazione:
Y. Kodaira et al., "Antigen-driven clonal accumulation of peritoneal gamma delta T cells in vivo", IMMUNOL INV, 28(2-3), 1999, pp. 137-148

Abstract

How the clonality of gamma delta T cells changes in response to exogenous antigens is uncertain. Here we analyzed kinetics of V gamma 1.1 and V gamma2 T cell clonality after intraperitoneal injection of purified protein derivatives (PPD) by the heterogeneity of the third complementarity determining region (CDR3) length in V gamma 1.1-J gamma 4-C gamma 4 and V gamma 2-J gamma 1-C gamma 1 junctions. The V-J junctions were analyzed in intrahepaticlymphocytes (IHL), spleen cells, and peritoneal exudate cells (PEC) by polyacrylamide gel electrophoresis. gamma delta T cells expressing V gamma 1.1and V gamma 2 genes were heterogeneous in normal mice. Accumulation of specific V gamma 1.1 T cell clones was transiently detected 7 days after the injection in PEG, but no accumulation was observed in IHL and spleen cells. The accumulated clones disappeared by 4 weeks. Transient accumulation of V gamma 2 T cell clones was also observed in PEC at the early phase after theinjection. These results suggest that gamma delta T cells with specific TCR respond to PPD and temporary accumulate in the peritoneal cavity. but notin liver and spleen.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/02/20 alle ore 15:03:31