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Titolo:
Positive selection drives the evolution of the Acp29AB accessory gland protein in Drosophila
Autore:
Aguade, M;
Indirizzi:
Univ Barcelona, Fac Biol, Dept Genet, E-08071 Barcelona, Spain Univ Barcelona Barcelona Spain E-08071 t Genet, E-08071 Barcelona, Spain
Titolo Testata:
GENETICS
fascicolo: 2, volume: 152, anno: 1999,
pagine: 543 - 551
SICI:
0016-6731(199906)152:2<543:PSDTEO>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
DNA-SEQUENCE; ALCOHOL-DEHYDROGENASE; MOLECULAR EVOLUTION; MALE REPRODUCTION; GENE REGION; ADH LOCUS; MELANOGASTER; POLYMORPHISM; DIVERGENCE; POPULATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Aguade, M UnivnBarcelona, Fac Biol, Dept Genet, Diagonal 645, E-08071 Barcelona, Spai Univ Barcelona Diagonal 645 Barcelona Spain E-08071 elona, Spai
Citazione:
M. Aguade, "Positive selection drives the evolution of the Acp29AB accessory gland protein in Drosophila", GENETICS, 152(2), 1999, pp. 543-551

Abstract

Nucleotide sequence variation at the Acp29AB gene region has been surveyedin Drosophila melanogaster from Spain (12 lines), Ivory Coast (14 lines), and Malawi (13 lines) and in one line of D. simulans. The similar to 1.7-kbregion studied encompasses the Acp29AB gene that codes for a male accessory gland protein and its flanking regions. Seventy-seven nucleotide and 8 length polymorphisms were detected. Nonsynonymous polymorphism was an order of magnitude lower than synonymous polymorphism, but still high relative to other non-sex-related genes. In D. melanogaster Variation at this region revealed no major genetic differentiation between East and West African populations, while differentiation was highly significant between the European and the two African populations. Comparison of polymorphism and divergence at synonymous and nonsynonymous sites showed an excess of fixed nonsynonymous changes, which indicates that the evolution of the Acp29AB protein has been driven by directional selection at least after the split of the D. melanogaster and D. simulans lineages. The pattern of variation in extant populations of D. melanogaster favors a scenario where the fixation of advantageous replacement substitutions occurred in the early stages of speciation andbalancing selection is maintaining variation in this species.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 13:06:07