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Titolo:
Postjunctional alpha(2)-adrenoceptors in the rat tail artery: effect of sex and castration
Autore:
Chen, DC; Duckles, SP; Krause, DN;
Indirizzi:
Univ Calif Irvine, Coll Med, Dept Pharmacol, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 ept Pharmacol, Irvine, CA 92697 USA
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 3, volume: 372, anno: 1999,
pagine: 247 - 252
SICI:
0014-2999(19990521)372:3<247:PAITRT>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
NOREPINEPHRINE RELEASE; BLOOD-VESSELS; INHIBITION; RESPONSES;
Keywords:
sex; alpha(2)-adrenoceptor; gonadal steroid; rauwolscine; idazoxan; UK-14304;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Duckles, SP Univ Calif Irvine, Coll Med, Dept Pharmacol, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 l, Irvine, CA 92697 USA
Citazione:
D.C. Chen et al., "Postjunctional alpha(2)-adrenoceptors in the rat tail artery: effect of sex and castration", EUR J PHARM, 372(3), 1999, pp. 247-252

Abstract

To investigate sex-related differences in vasoconstrictor responses to postjunctional alpha(2)-adrenoceptor activation, isolated ring segments of tail arteries from Fischer-344 rats were studied. Addition of the alpha(2)-adrenoceptor agonist, UK-14304 [5-bromo-6-(2-imidazoline-2yl)-aminol-quinoxaline], enhanced vasoconstriction to the selective alpha(1)-adrenoceptor agonist, methoxamine, in arteries from both males and females. The response to UK-14304 was significantly greater in arteries from males as compared to female arteries. Addition of alpha(2)-adrenoceptor antagonist, idazoxan or rauwolscine, shifted norepinephrine concentration response curves to the right. Antagonist effects also tended to be greater in arteries from males as compared to females. After gonadectomy, male-female differences persisted; thus, removal of sex hormones in either males or females did not alter responses to either agonists or antagonists of alpha(2)-adrenoceptors. These findings suggest that sex differences in alpha(2)-adrenoceptor function are notmaintained by either male or female gonadal steroid hormones but may be developmentally regulated. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 16:08:35