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Titolo:
Prognostic factors in ductal carcinoma in situ of the breast: results of aretrospective study of 575 cases
Autore:
Bonnier, P; Body, G; Bessenay, F; Charpin, C; Fetissof, F; Beedassy, B; Lejeune, C; Piana, L;
Indirizzi:
Hop Concept, Serv Gynecol & Obstet, F-13385 Marseille 5, France Hop Concept Marseille France 5 col & Obstet, F-13385 Marseille 5, France
Titolo Testata:
EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY
fascicolo: 1, volume: 84, anno: 1999,
pagine: 27 - 35
SICI:
0301-2115(199905)84:1<27:PFIDCI>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
INSITU INTRADUCTAL CARCINOMA; IN-SITU; CONSERVING SURGERY; DEFINITIVE IRRADIATION; ESTROGEN-RECEPTOR; LOCAL RECURRENCE; FOLLOW-UP; CANCER; MULTICENTRICITY; CLASSIFICATION;
Keywords:
breast cancer; breast-conserving surgery; ductal carcinoma in situ; prognostic factors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Bonnier, P Hopranceept, Serv Gynecol & Obstet, 147 Blvd Baille, F-13385 Marseille 5, F Hop Concept 147 Blvd Baille Marseille France 5 Marseille 5, F
Citazione:
P. Bonnier et al., "Prognostic factors in ductal carcinoma in situ of the breast: results of aretrospective study of 575 cases", EUR J OB GY, 84(1), 1999, pp. 27-35

Abstract

Objective. Conservative treatment for ductal carcinoma in situ of the breast exposes patients to the risk of infiltrating recurrence which can lead to metastasis. The primary purposes of this retrospective study were to evaluate diagnostic and therapeutic methods over a 10-year period and to validate prognostic factors. This information should greatly improve patient selection for conservative treatment or mastectomy. Study design. A multi-institutional data base including 575 patients treated between 1983 and 1993 wasestablished by combining data from 16 French institutions. Survival at 5 and 7 years was studied as a function of various prognostic factors. Results. Recurrence-free survival at 7 years was 0.96 after modified radical mastectomy and 0.83 after breast-conserving treatment and radiotherapy (P=0.003). Metastasis-free survival at 7 years was 0.99 after modified radical mastectomy and 0.94 after breast-conserving treatment and radiotherapy (not significant). No factor was predictive of local recurrence after mastectomy. Clinical stage was the only; factor significantly correlated with metastasis after mastectomy. Recurrence-free survival after breast-conserving treatment with radiotherapy was significantly lower for patients with comedo carcinoma, multifocal lesions, or unclear resection margins, regardless of whether the histological type was comedo or non-comedo carcinoma. Metastasis-freesurvival was significantly lower for patients with multifocal lesions and for patients with unclear margins after excision of comedo carcinoma. Conclusions. Breast-conserving treatment with radiotherapy is a valid alternative to mastectomy. Patients must be selected carefully on the basis of morphological criteria. Swift gains in therapeutic outcome can be obtained by stressing quality control at each stage of diagnosis and treatment. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 13:09:11