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Titolo:
T cell antigen-receptor signal transduction
Autore:
van Leeuwen, JEM; Samelson, LE;
Indirizzi:
NCI, Lab Cellular & Mol Biol, NIH, Bethesda, MD 20892 USA NCI Bethesda MDUSA 20892 ellular & Mol Biol, NIH, Bethesda, MD 20892 USA
Titolo Testata:
CURRENT OPINION IN IMMUNOLOGY
fascicolo: 3, volume: 11, anno: 1999,
pagine: 242 - 248
SICI:
0952-7915(199906)11:3<242:TCAST>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHOSPHOTYROSINE-BINDING DOMAIN; ADAPTER PROTEIN SLP-76; TYROSINE KINASE ZAP-70; SYK FAMILY KINASES; MOLECULAR-CLONING; DEFICIENT MICE; MEDIATED ACTIVATION; PLASMA-MEMBRANE; C-CBL; PHOSPHORYLATION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
81
Recensione:
Indirizzi per estratti:
Indirizzo: van Leeuwen, JEM NCI,ethesda,lular & Mol Biol, NIH, Bldg 37,Room 1E24,9000Rockville Pike, B NCI Bldg 37,Room 1E24,9000 Rockville Pike Bethesda MD USA 20892
Citazione:
J.E.M. van Leeuwen e L.E. Samelson, "T cell antigen-receptor signal transduction", CURR OP IM, 11(3), 1999, pp. 242-248

Abstract

During the past year, major progress has been made in understanding proximal TCR signal-transduction events. Cbl has been identified as a negative regulator of kinases from the ZAP-70/Syk family. Studies on. LAT, SLP-76, Itkand Vav have revealed their role in the activation of Ras and phospholipase-C gamma 1-Ca2+ signalling pathways, TCR-induced cytoskeletal changes involve signalling through SLP-76-Vav-Nck to activate effecters of the Rho-family of GTPases. Finally, glycolipid-enriched microdomains play a crucial role in T cell activation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 20:09:55