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Titolo:
Apoptosis of Mycobacterium avium-infected macrophages is mediated by both tumour necrosis factor (TNF) and Fas, and involves the activation of caspases
Autore:
Bermudez, LE; Parker, A; Petrofsky, M;
Indirizzi:
Califcisco,ic Med Ctr, Res Inst, Kuzell Inst Arthrit & Infect Dis, San Fran Calif Pacific Med Ctr San Francisco CA USA 94115 t & Infect Dis, San Fran
Titolo Testata:
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
fascicolo: 1, volume: 116, anno: 1999,
pagine: 94 - 99
SICI:
0009-9104(199904)116:1<94:AOMAMI>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERLEUKIN-1-BETA CONVERTING-ENZYME; SHIGELLA-FLEXNERI; CELL-DEATH; EXPRESSION; RECEPTORS; TUBERCULOSIS; MONOCYTES; PROTEASES; GROWTH;
Keywords:
apoptosis; Mycabacterium avium; macrophages; caspases;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Bermudez, LE Califsterific Med Ctr, Res Inst, Kuzell Inst Arthrit & InfectDis, 2200 Web Calif Pacific Med Ctr 2200 Webster St,Suite 305 San Francisco CA USA 94115
Citazione:
L.E. Bermudez et al., "Apoptosis of Mycobacterium avium-infected macrophages is mediated by both tumour necrosis factor (TNF) and Fas, and involves the activation of caspases", CLIN EXP IM, 116(1), 1999, pp. 94-99

Abstract

Mycobacterium avium causes disseminated infection in AIDS patients and several forms of infection in immunocompetent hosts. Recent studies have shownthat M. avium infection of macrophages in vitro leads to apoptosis of significant numbers of infected cells. Several strains of M. avium used to infect human macrophages for 5 days (multiplicity of infection of 10) triggered28-46% higher levels of apoptosis than observed with uninfected macrophages at the same time points. Mycobacterium avium strains unable to replicate intracellularly (rep(-)) resulted in a 15% rate of apoptosis, while M. smegmatis-infected monolayers showed the same percentage of apoptotic cells as the uninfected macrophage control. The presence of anti-TNF-alpha antibody reduced apoptosis to 17% and the presence of anti-Fas antibody reduced apoptosis to 10%. When both antibodies were used together, the apoptosis level was 5% above the control. Treatment with TGF-beta also reduced the number of apoptotic cells in infected monolayers. If intracellular growth was inhibited, apoptosis of macrophages decreased significantly. It was also shown that apoptosis was associated with IL-1 beta-converting enzyme (ICE) activation and was significantly reduced by a caspase inhibitor. Gaining understanding of the mechanisms of M. avium-associated apoptosis of macrophages willprovide important insight into M. avium pathogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 04:19:48