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Titolo:
Rapid intestinal ischaemia-reperfusion injury is suppressed in geneticallymast cell-deficient Ws/Ws rats
Autore:
Andoh, A; Kimura, T; Fukuda, M; Araki, Y; Fujiyama, Y; Bamba, T;
Indirizzi:
Shiga Univ Med Sci, Dept Internal Med, Otsu, Shiga 5202192, Japan Shiga Univ Med Sci Otsu Shiga Japan 5202192 d, Otsu, Shiga 5202192, Japan
Titolo Testata:
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
fascicolo: 1, volume: 116, anno: 1999,
pagine: 90 - 93
SICI:
0009-9104(199904)116:1<90:RIIIIS>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
TYROSINE KINASE DOMAIN; ISCHEMIA-REPERFUSION; SUPEROXIDE GENERATION; HISTAMINE-RELEASE; HEPATIC ISCHEMIA; KUPFFER CELLS; C-KIT; NEUTROPHILS; DYSFUNCTION; CONTRIBUTE;
Keywords:
mucosal mast cell; RMCP-II; permeability;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Andoh, A Shiga Univ Med Sci, Dept Internal Med, Otsu, Shiga 5202192, JapanShiga Univ Med Sci Otsu Shiga Japan 5202192 Shiga 5202192, Japan
Citazione:
A. Andoh et al., "Rapid intestinal ischaemia-reperfusion injury is suppressed in geneticallymast cell-deficient Ws/Ws rats", CLIN EXP IM, 116(1), 1999, pp. 90-93

Abstract

Ws/Ws rats have a small deletion of the c-kit gene, and are deficient in both mucosal and connective tissue-type mast cells. In this study, the role of mucosal type mast cells (MMC) in the development of intestinal ischaemia-reperfusion injury was investigated in Ws/Ws rats. Autoperfused segments of the jejunum were exposed to 60 min of ischaemia, followed by reperfusion for various time periods. The epithelial permeability was then assessed by the Cr-51-EDTA clearance rate. In the control (+/+) rats, the maximal increase in mucosal permeability was achieved at 45 min of reperfusion. In contrast, this increase was significantly and potently attenuated in the Ws/Ws rats. Mucosal alkaline phosphatase activity decreased in the control (+/+) rats, but was not altered in the Ws/Ws rats. There were no differences in mucosal myeloperoxidase activity, indicating that granulocytes did not contribute to tissue injury. These results provide direct evidence for the role of mast cells in the pathogenesis of intestinal ischaemia-reperfusion injury.

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Documento generato il 29/03/20 alle ore 23:41:47