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Titolo:
Metabolism and pharmacokinetics of selective serotonin reuptake inhibitors
Autore:
DeVane, CL;
Indirizzi:
Med Univ S Carolina, Dept Psychiat & Behav Sci, Charleston, SC 29425 USA Med Univ S Carolina Charleston SC USA 29425 Sci, Charleston, SC 29425 USA
Titolo Testata:
CELLULAR AND MOLECULAR NEUROBIOLOGY
fascicolo: 4, volume: 19, anno: 1999,
pagine: 443 - 466
SICI:
0272-4340(199908)19:4<443:MAPOSS>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; HUMAN LIVER-MICROSOMES; SPARTEINE OXIDATION POLYMORPHISM; ELECTRON-CAPTURE DETECTION; UPTAKE BLOCKER SERTRALINE; SOLID-PHASE EXTRACTION; HYDROXYLATION IN-VITRO; HUMAN-PLASMA; GAS-CHROMATOGRAPHY; FLUVOXAMINE MALEATE;
Keywords:
selective serotonin reuptake inhibitors; metabolism; pharmacokinetics; fluoxetine; fluvoxamine; paroxetine; sertraline; citalopram; cytochrome P450;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
121
Recensione:
Indirizzi per estratti:
Indirizzo: DeVane, CL MedAUniv S Carolina, Dept Psychiat, 171 Ashley Ave, Charleston,SC 29425 US Med Univ S Carolina 171 Ashley Ave Charleston SC USA 29425 5 US
Citazione:
C.L. DeVane, "Metabolism and pharmacokinetics of selective serotonin reuptake inhibitors", CELL MOL N, 19(4), 1999, pp. 443-466

Abstract

1. Five drugs with the predominant pharmacologic effect of inhibiting the neuronal reuptake of serotonin are available worldwide for clinical use. This class of psychoactive drugs, known as selective serotonin reuptake inhibitors (SSRIs), is comprised of fluoxetine, sertraline, paroxetine, fluvoxamine, and citalopram.2. The SSRIs appear to share similar pharmacodynamic properties which translate to efficacy in the treatment of depression and anxiety syndromes. Thedrugs are differentiated by their pharmacokinetic properties with regard to stereochemistry, metabolism, inhibition of cytochrome enzymes, and participation in drug-drug interactions. Studies focusing on the relationship of plasma drug concentration to therapeutic and adverse effects have not confirmed the value of plasma concentration monitoring.3. This review summarizes the metabolism and relevant pharmacokinetic properties of the SSRIs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 07:26:34