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Titolo:
The use of optical spectroscopy in combinatorial chemistry
Autore:
Gremlich, HU;
Indirizzi:
Novartis Pharma AG, CH-4002 Basel, Switzerland Novartis Pharma AG Basel Switzerland CH-4002 CH-4002 Basel, Switzerland
Titolo Testata:
BIOTECHNOLOGY AND BIOENGINEERING
fascicolo: 3, volume: 61, anno: 1998,
pagine: 179 - 187
SICI:
0006-3592(1998)61:3<179:TUOOSI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
SOLID-PHASE REACTIONS; SINGLE BEAD IR; RESIN SUPPORTS; FTIR MICROSPECTROSCOPY; INFRARED-ANALYSIS; ORGANIC-REACTIONS; TOOLS;
Keywords:
combinatorial chemistry; solid-phase synthesis; infrared spectroscopy; Raman spectroscopy; HPLC-FTIR; fluorescence spectroscopy; direct spectral analysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Gremlich, HU Novartis Pharma AG, POB, CH-4002 Basel, Switzerland Novartis Pharma AG POB Basel Switzerland CH-4002 Switzerland
Citazione:
H.U. Gremlich, "The use of optical spectroscopy in combinatorial chemistry", BIOTECH BIO, 61(3), 1998, pp. 179-187

Abstract

Infrared and Raman spectroscopy allow direct spectral analysis of the solid-phase, thus avoiding the tedious cleavage of compounds from the solid support. With diagnostic bands in starting materials or products, infrared andRaman spectroscopy are efficient in monitoring each reaction step directlyon the solid phase. Consequently, infrared and Raman spectroscopy have evolved as the premier analytical methodology for direct analysis on the solidsupport. While infrared transmission spectroscopy is a general analytical method for resin samples, internal reflection spectroscopy is especially suited for solid polymer substrates known as "pins" or "crowns. " Single bead analysis is done best by infrared microspectroscopy, whereas photoacoustic spectroscopy allows totally nondestructive analysis of resin samples. With an automated accessory, diffuse reflection spectroscopy provides a method for high throughput on-bead monitoring of solid-phase reactions. Providing identification based on molecular structure, HPLC-FTIR is, therefore, complementary to LC-MS. Additionally, Raman spectroscopy as a complement to infrared spectroscopy can be applied to resin samples and-using a Raman microscope-to single beads. Fluorometry as an extremely sensitive spectroscopic detection method allows rapid quantification of organic reactions directly on the resin. (C) 1999John Wiley & Sons, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 14:28:02