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Titolo:
Comparison of two sensitization paradigms of the acoustic startle responsein Wistar and Sprague-Dawley rats
Autore:
Pilz, PKD; Linke, R; Yilmazer-Hanke, DM; Schwegler, H;
Indirizzi:
Univ Tubingen, Inst Zool, D-72076 Tubingen, Germany Univ Tubingen Tubingen Germany D-72076 t Zool, D-72076 Tubingen, Germany Univ Magdeburg, Inst Anat, D-39120 Magdeburg, Germany Univ Magdeburg Magdeburg Germany D-39120 nat, D-39120 Magdeburg, Germany
Titolo Testata:
BEHAVIOR GENETICS
fascicolo: 1, volume: 29, anno: 1999,
pagine: 59 - 63
SICI:
0001-8244(199901)29:1<59:COTSPO>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
STRAINS; HABITUATION; REFLEX; WITHDRAWAL; AVOIDANCE; AGE;
Keywords:
acoustic startle response; habituation; sensitization; fear; generic differences;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Pilz, PKD Univ Tubingen, Inst Zool, Morgenstelle 28, D-72076 Tubingen, Germany Univ Tubingen Morgenstelle 28 Tubingen Germany D-72076 Germany
Citazione:
P.K.D. Pilz et al., "Comparison of two sensitization paradigms of the acoustic startle responsein Wistar and Sprague-Dawley rats", BEHAV GENET, 29(1), 1999, pp. 59-63

Abstract

An increase in general responsiveness after aversive stimulation has provided a most widely accepted and well-understood sensitization paradigm. According to a second paradigm (based on the dual process theory of habituationand sensitization), not only additional aversive stimuli, but also the response-eliciting stimuli themselves, induce sensitization. To relate these two sensitization paradigms, we compared the course of startle response parameters during repetitive acoustic stimulation with the change in startle amplitude after electric footshocks in outbred Wistar and Sprague-Dawley rats. Compared to the Wistar rats used, the Sprague-Dawley rats showed a lower response decrement and a shortened latency during repetitive stimulation, both of which are indicators of increased sensitization by the startle-eliciting stimuli. In addition, the Sprague-Dawley rats also demonstrated a reduced increase in startle amplitude following footshock. This was postulated to be a consequence of the strong sensitization by startle-eliciting stimuli, which interferes with sensitization elicited by footshock. Because our Wistar and Sprague-Dawley rats did not differ in initial startle amplitude, but mainly in susceptibility to sensitization, further comparisons of thesegenetically different stocks of rats seem to be of potential value in studying differences in fear-motivated behavior.

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Documento generato il 29/03/20 alle ore 09:11:04