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Titolo:
Humoral response of Meriones libycus to experimental infection with Leishmania major
Autore:
Al-Younes, H; Saliba, EK; Al-Khateeb, M; Khoury, S; Oumeish, OY; Othman, M;
Indirizzi:
Univ Jordan, Dept Biol Sci, Amman 11942, Jordan Univ Jordan Amman Jordan11942 ordan, Dept Biol Sci, Amman 11942, Jordan Univ Jordan, Dept Pathol & Microbiol, Amman 11942, Jordan Univ Jordan Amman Jordan 11942 t Pathol & Microbiol, Amman 11942, Jordan Univ Jordan, Dept Community Med, Amman 11942, Jordan Univ Jordan Amman Jordan 11942 , Dept Community Med, Amman 11942, Jordan Jordan Dermatol Soc, Amman, Jordan Jordan Dermatol Soc Amman JordanJordan Dermatol Soc, Amman, Jordan Univ Michigan, Dept Ophthalmol, Ann Arbor, MI 48109 USA Univ Michigan AnnArbor MI USA 48109 Ophthalmol, Ann Arbor, MI 48109 USA
Titolo Testata:
ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY
fascicolo: 3, volume: 93, anno: 1999,
pagine: 239 - 245
SICI:
0003-4983(199904)93:3<239:HROMLT>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
ZOONOTIC CUTANEOUS LEISHMANIASIS; SAUDI-ARABIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Saliba, EK Univ Jordan, Dept Biol Sci, POB 13057, Amman 11942, Jordan UnivJordan POB 13057 Amman Jordan 11942 , Amman 11942, Jordan
Citazione:
H. Al-Younes et al., "Humoral response of Meriones libycus to experimental infection with Leishmania major", ANN TROP M, 93(3), 1999, pp. 239-245

Abstract

The humoral responses of laboratory-reared jirds (Meriones libycus) to inoculation with various doses of Leishmania major were determined. The animals were inoculated intradermally with 10(2), 10(3), 10(5) or 10(7) promastigotes of a strain of L. major originally isolated from a Jordanian patient. The jirds were then bled at various intervals throughout the 26 weeks of the study, and the sera checked, by IFAT, for antibodies to homologous parasites. There were no detectable humoral responses in the animals inoculated with 10(2) promastigotes each or in parasite-free controls but a positive response was apparent in each of the other jirds. The animals given 10(3) promastigotes each required 3 months to become IFAT-positive whereas those given 10(5) and 10(7) parasites only needed 4 and 2 weeks, respectively. More than 50% of the animals inoculated with 10(3) parasites each developed strongly positive sera 2 months post-infection, whereas > 50% of the animals inoculated with 10(5) or 10(7) parasites each had strongly or very strongly positive sera 4 and 2 weeks post-inoculation, respectively. The data indicate that, in M. libycus inoculated with L. major, the time required for the humoral response to develop and its intensity are both dose-related.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 16:08:07