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Titolo:
Apoptotic neurodegeneration following trauma is markedly enhanced in the immature brain
Autore:
Bittigau, D; Sifringer, M; Pohl, D; Stadthaus, D; Ishimaru, M; Shimizu, H; Ikeda, M; Lang, D; Speer, A; Olney, JW; Ikonomidou, C;
Indirizzi:
Humboldt Univ, Childrens Hosp, Dept Pediat Neurol, D-13353 Berlin, GermanyHumboldt Univ Berlin Germany D-13353 iat Neurol, D-13353 Berlin, Germany Tech Fachhsch Berlin, Berlin, Germany Tech Fachhsch Berlin Berlin Germany ch Fachhsch Berlin, Berlin, Germany Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA WashingtonUniv St Louis MO USA 63110 pt Psychiat, St Louis, MO 63110 USA Eisai & Co Ltd, Tsukuba Res Labs Drug Discovery, Ibaraki, Osaka, Japan Eisai & Co Ltd Ibaraki Osaka Japan Drug Discovery, Ibaraki, Osaka, Japan
Titolo Testata:
ANNALS OF NEUROLOGY
fascicolo: 6, volume: 45, anno: 1999,
pagine: 724 - 735
SICI:
0364-5134(199906)45:6<724:ANFTIM>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICAL IMPACT INJURY; SPINAL-CORD INJURY; METHYL-D-ASPARTATE; REGIONAL CEREBRAL EDEMA; DEVELOPING RAT-BRAIN; CLOSED-HEAD INJURY; INDUCED CELL-DEATH; C-JUN; NONCOMPETITIVE BLOCKADE; TRANSCRIPTION FACTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
86
Recensione:
Indirizzi per estratti:
Indirizzo: Ikonomidou, C Humboldturger, Childrens Hosp, Dept Pediat Neurol, Virchow Campus,Augustenb Humboldt Univ Virchow Campus,Augustenburger Pl 1 Berlin Germany D-13353
Citazione:
D. Bittigau et al., "Apoptotic neurodegeneration following trauma is markedly enhanced in the immature brain", ANN NEUROL, 45(6), 1999, pp. 724-735

Abstract

Age dependency of apoptotic neurodegeneration was studied in the developing rat brain after percussion head trauma. In 7-day-old rats, mechanical trauma, applied by means of a weight drop device, was shown to trigger widespread cell death in the hemisphere ipsilateral to the trauma site, which first appeared at 6 hours, peaked at 24 hours, and subsided by 5 days after trauma. Ultrastructurally, degenerating neurons displayed features consistent with apoptosis. A decrease of bcl-2 in conjunction with an increase of c-jun mRNA levels, which were evident at 1 hour after trauma and were accompanied by elevation of CPP 32-like proteolytic activity and oligonucleosomes invulnerable brain regions, confirmed the apoptotic nature of this process, Severity of trauma-triggered apoptosis in the brains of 3- to 30-day-old rats was age dependent, was highest in 3- and 7-day-old animals, and demonstrated a subsequent rapid decline. Adjusting the mechanical force in accordance with age-specific brain weights revealed a similar vulnerability profile. Thus, apoptotic neurodegeneration contributes in an age-dependent fashionto neuropathological outcome after head trauma, with the immature brain being exceedingly vulnerable. These results help explain unfavorable outcomesof very young pediatric head trauma patients and imply that, in this group, an antiapoptotic regimen may constitute a successful neuroprotective approach.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:28:15