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Titolo:
H+-K+-ATPases: regulation and role in pathophysiological states
Autore:
Silver, RB; Soleimani, M;
Indirizzi:
Univ Cincinnati, Dept Med, Cincinnati, OH 45267 USA Univ Cincinnati Cincinnati OH USA 45267 ept Med, Cincinnati, OH 45267 USA Cornell Univ, Coll Med, Dept Physiol & Biophys, New York, NY 10021 USA Cornell Univ New York NY USA 10021 siol & Biophys, New York, NY 10021 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
fascicolo: 6, volume: 45, anno: 1999,
pagine: F799 - F811
SICI:
0363-6127(199906)45:6<F799:HRARIP>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDULLARY COLLECTING DUCT; RENAL BICARBONATE REABSORPTION; DISTAL NEPHRON SEGMENTS; POTASSIUM-DEPLETION; ADENOSINE-TRIPHOSPHATASE; INTERCALATED CELLS; FUNCTIONAL EXPRESSION; GASTRIC H+,K+-ATPASE; SODIUM RETENTION; PROTON SECRETION;
Keywords:
proton-potassium-adenosinetriphosphatase kidney; potassium depletion; sodium depletion; acid-base homeostasis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
86
Recensione:
Indirizzi per estratti:
Indirizzo: Soleimani, M Univve,MSBnnati, Dept Internal Med, Div Nephrol & Hypertens, 231 Bethesda A Univ Cincinnati 231 Bethesda Ave,MSB 5502 Cincinnati OH USA 45267
Citazione:
R.B. Silver e M. Soleimani, "H+-K+-ATPases: regulation and role in pathophysiological states", AM J P-REN, 45(6), 1999, pp. F799-F811

Abstract

Molecular cloning experiments have identified the existence of two H+-K+-ATPases (HKAs), colonic and gastric. Recent functional and molecular studiesindicate the presence of both transporters in the kidney, which are presumed to mediate the exchange of intracellular H+ for extracellular K+. On thebasis of these studies, a picture is evolving that indicates differential regulation of HKAs at the molecular level in acid-base and electrolyte disorders. Of the two transporters, gastric HKA is expressed constitutively along the length of the collecting duct and is responsible for H+ secretion and K+ reabsorption under normal conditions and may be stimulated with acid-base perturbations and/or K+ depletion. This regulation may be species specific. To date there are no data to indicate that the colonic HKA (HKAc) plays a role in H+ secretion or K+ reabsorption under normal conditions. However, HKAc shows adaptive regulation in pathophysiological conditions such as Kt depletion, NaCl deficiency, and proximal renal tubular acidosis, suggesting an important role for this exchanger in potassium, HCO3- and sodium (orchloride) reabsorption in disease states. The purpose of this review is tosummarize recent functional and molecular studies on the regulation of HKAs in physiological and pathophysiological states. Possible signals responsible far regulation of HKAs in these conditions will be discussed. Furthermore, the role of these transporters in acid-base and electrolyte homeostasiswill be evaluated in the context of genetically altered animals deficient in HKAc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 17:31:19