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Titolo:
Isoproterenol potentiates alpha-adrenergic and muscarinic receptor-mediated Ca2+ response in rat parotid cells
Autore:
Tanimura, A; Nezu, A; Tojyo, Y; Matsumoto, Y;
Indirizzi:
Hlth610293,iv Hokkaido, Sch Dent, Dept Dent Pharmacol, Ishikari, Hokkaido 0 Hlth Sci Univ Hokkaido Ishikari Hokkaido Japan 0610293 hikari, Hokkaido 0
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
fascicolo: 6, volume: 45, anno: 1999,
pagine: C1282 - C1287
SICI:
0363-6143(199906)45:6<C1282:IPAAMR>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT PROTEIN-KINASE; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS; VASOACTIVE INTESTINAL PEPTIDE; CYCLIC-AMP; ACINAR-CELLS; AMYLASE RELEASE; SUBSTANCE-P; CALCIUM MOBILIZATION; CA-2+ MOBILIZATION; SALIVARY SECRETION;
Keywords:
beta-adrenergic receptor; adenosine 3 ',5 '-cyclic monophosphate; calcium release; potentiation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Tanimura, A Hlth610293,iv Hokkaido, Sch Dent, Dept Dent Pharmacol, Ishikari, Hokkaido 0 Hlth Sci Univ Hokkaido Ishikari Hokkaido Japan 0610293 aido 0
Citazione:
A. Tanimura et al., "Isoproterenol potentiates alpha-adrenergic and muscarinic receptor-mediated Ca2+ response in rat parotid cells", AM J P-CELL, 45(6), 1999, pp. C1282-C1287

Abstract

The effects of the cAMP pathway on the Ca2+ response elicited by phospholipase C-coupled receptor stimulations were studied in rat parotid cells. Although 1 mu M isoproterenol (Iso) itself had no effect on the cytosolic Ca2concentration, the pretreatment with Iso potentiated Ca2+ responses evokedby phenylephrine. The potentiating effect of Iso was attributed to a shifting of the concentration-response curves of phenylephrine to the left and an increase in the maximal response. Half-maximal potentiation occurred at 3nM Iso. Iso also potentiated the Ca2+ response elicited by carbachol. The potentiating effect of Iso was mimicked by forskolin (10 mu M) and dibutyryl adenosine 3',5'-cyclic monophosphate (2 mM) and was blocked by 10 mu M H-89. Iso potentiated the phenylephrine-induced Ca2+ response in the absence of extracellular Ca2+, but Iso did not increase the inositol trisphosphate (IP3) production induced by phenylephrine. These results suggest that the potentiation of the Ca2+ response can be attributed to a sensitization of IP3 receptors by cAMP-dependent protein kinase.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/05/20 alle ore 15:03:31