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Titolo:
Allergen-induced accumulation of eosinophils and lymphocytes in skin chambers is associated with increased levels of interleukin-4 and sVCAM-1
Autore:
Fernvik, E; Hallden, G; Lundahl, J; Raud, J; Alkner, U; van Hage-Hamsten, M; Gronneberg, R;
Indirizzi:
Karolinska Hosp & Inst, Dept Lab Med, Div Clin Immunol, Stockholm, Sweden Karolinska Hosp & Inst Stockholm Sweden Clin Immunol, Stockholm, Sweden Astra Pain Control AB, Discovery Div, Sodertalje, Sweden Astra Pain Control AB Sodertalje Sweden scovery Div, Sodertalje, Sweden Astro Draco AB, Bioanalyt Chem, Lund, Sweden Astro Draco AB Lund SwedenAstro Draco AB, Bioanalyt Chem, Lund, Sweden Huddinge86niv Hosp, Karolinska Inst, Dept Med, Div Resp & Allerg Dis, S-141 Huddinge Univ Hosp Huddinge Sweden S-14186 Div Resp & Allerg Dis, S-141
Titolo Testata:
ALLERGY
fascicolo: 5, volume: 54, anno: 1999,
pagine: 455 - 463
SICI:
0105-4538(199905)54:5<455:AAOEAL>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-ADHESION MOLECULES; BLOOD EOSINOPHILS; ENDOTHELIAL-CELLS; ATOPIC ASTHMA; IGE; HISTAMINE; IL-4; INFLAMMATION; NEUTROPHILS; RECRUITMENT;
Keywords:
eosinophils; histamine; interleukin-4; lymphocytes; alpha(2)-macroglobulin; skin chamber; sVCAM-1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Fernvik, E Karolinska Hosp, Dept Clin Immunol, L2-01, S-17176 Stockholm, Sweden Karolinska Hosp L2-01 Stockholm Sweden S-17176 ockholm, Sweden
Citazione:
E. Fernvik et al., "Allergen-induced accumulation of eosinophils and lymphocytes in skin chambers is associated with increased levels of interleukin-4 and sVCAM-1", ALLERGY, 54(5), 1999, pp. 455-463

Abstract

Background: The aim of the study was to characterize the kinetic accumulation of various inflammatory mediators in allergen-challenged skin chambers applied on patients with pollen-related allergic rhinitis/mild asthma. Methods: Skin blisters were induced on the forearms and challenged with allergen or phosphate-buffered saline (PBS). Peripheral blood was drawn before and 8 h after challenge for analysis of differential cell counts, sVCAM-1, and alpha(2)-macroglobulin. Chamber fluids, collected at 1, 4, and 8 h after allergen application, were analyzed for differential cell counts, histamine, interleukin (IL)-4, sVCAM-1, and alpha(2)-macroglobulin. Results: The number of recruited leukocytes was equal in allergen and PBS chambers; however, the numbers of eosinophils and lymphocytes were significantly (P less than or equal to 0.05) elevated in allergen-challenged chambers at 8 h. Compared to PBS chambers, allergen chambers contained significantly (P<0.01-0.05) higher levels of histamine (at 1 and 4 h), IL-4 (at 4 and8 h), alpha(2)-macroglobulin (at 1 and 8 h), and sVCAM-1 (at 1 and 8 h). In contrast to alpha(2)-macroglobulin, levels of sVCAM-1 in peripheral bloodwere significantly (P<0.05) increased at 8 h. Conclusions: Increased levels of sVCAM-1 and IL-4 in allergen-challenged chambers, in parallel with increased recruitment of eosinophils and lymphocytes, points to the participation of IL-4 and VCAM-1 in the development of the late-phase reaction. Increased levels of sVCAM-1 in allergen-challenged chambers probably reflects a combination of leakage and local production.

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Documento generato il 26/09/20 alle ore 05:22:56