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Titolo:
Effects of molybdate and pentachlorophenol on the sulfation of alpha-naphthol
Autore:
Boles, JW; Klaassen, CD;
Indirizzi:
Univ Kansas, Med Ctr, Ctr Environm & Occupat Hlth, Dept Pharmacol Toxicol & Univ Kansas Kansas City KS USA 66160 cupat Hlth, Dept Pharmacol Toxicol &
Titolo Testata:
TOXICOLOGY LETTERS
fascicolo: 1, volume: 106, anno: 1999,
pagine: 1 - 8
SICI:
0378-4274(19990520)106:1<1:EOMAPO>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISOLATED RAT HEPATOCYTES; INORGANIC SULFATE; LIVER; CONJUGATION; INHIBITOR; HARMOL; INVIVO; N-HYDROXY-2-ACETYLAMINOFLUORENE; 2,6-DICHLORO-4-NITROPHENOL; 5'-PHOSPHOSULFATE;
Keywords:
molybdate; alpha-naphthol; pentachlorophenol; sulfation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Klaassen, CD Univ Kansas, Med Ctr, Ctr Environm & Occupat Hlth, Dept Pharmacol Toxicol & Univ Kansas 3901 Rainbow Blvd Kansas City KS USA 66160 icol &
Citazione:
J.W. Boles e C.D. Klaassen, "Effects of molybdate and pentachlorophenol on the sulfation of alpha-naphthol", TOX LETT, 106(1), 1999, pp. 1-8

Abstract

Sulfation is the conjugation of chemicals with sulfate, which usually decreases, but occasionally increases, their biological effects. The phenol-sulfotransferase inhibitor pentachlorophenol (PCP) is often used to distinguish the biological effects of a chemical from its sulfate conjugate. Recently, molybdate has been shown to decrease the hepatic concentration of 3'-phosphoadenosine 5'-phosphosulfate (PAPS), the cosubstrate for sulfation. Therefore, the present study was designed to compare the effectiveness and specificity of molybdate and PCP as inhibitors of sulfation. alpha-Naphthol (125and 250 mu mol/kg, i.p.) was administered to rats and the sulfate and glucuronide conjugates excreted into urine were quantified for this comparison. Molybdate (5.0, 7.5, and 10 mmol/kg) decreased the 24-h cumulative urinaryexcretion of the sulfate conjugate of the lower dose of alpha-naphthol by 54, 53, and 55%, respectively, with corresponding compensatory increases inglucuronide excretion at the two lower doses of molybdate. PCP (20, 40, and 80 mu mol/kg) similarly decreased the sulfation of alpha-naphthol by 48, 38, and 41%, respectively, but prevented compensatory increases in glucuronide excretion. Molybdate (2.5, 5.0, and 7.5 mmol/kg) decreased the sulfation of the higher dose of alpha-naphthol by 21, 30, and 44%, respectively, again with corresponding compensatory increases in glucuronide excretion. In contrast, PCP did not decrease significantly the sulfation of the higher dose of alpha-naphthol. These data suggest that molybdate is equally or more effective than PCP at inhibiting sulfation of alpha-naphthol, and appears to be more specific. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 08:40:25