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Titolo:
Effects of 5,7-dihydroxytryptamine depletion of tissue serotonin levels onextracellular serotonin in the striatum assessed with in vivo microdialysis: Relationship to behavior
Autore:
Hall, FS; DeVries, AC; Fong, GW; Huang, S; Pert, A;
Indirizzi:
NIAAA, DICBR, Clin Studies Lab, Bethesda, MD 20892 USA NIAAA Bethesda MD USA 20892 CBR, Clin Studies Lab, Bethesda, MD 20892 USA NIMH, Biol Psychiat Branch, Bethesda, MD 20892 USA NIMH Bethesda MD USA 20892 , Biol Psychiat Branch, Bethesda, MD 20892 USA
Titolo Testata:
SYNAPSE
fascicolo: 1, volume: 33, anno: 1999,
pagine: 16 - 25
SICI:
0887-4476(199907)33:1<16:EO5DOT>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIAN RAPHE NUCLEI; ELEVATED PLUS-MAZE; 5-HYDROXYINDOLEACETIC ACID; LOCOMOTOR-ACTIVITY; BRAIN-SEROTONIN; 6-OHDA LESION; MDMA ECSTASY; RAT; 5-HYDROXYTRYPTAMINE; DOPAMINE;
Keywords:
serotonin; microdialysis; anxiety; recovery;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Hall, FS NIDA, IRP, Mol Neurobiol Branch, POB 5180, Baltimore, MD 21224 USA NIDA POB 5180 Baltimore MD USA 21224 180, Baltimore, MD 21224 USA
Citazione:
F.S. Hall et al., "Effects of 5,7-dihydroxytryptamine depletion of tissue serotonin levels onextracellular serotonin in the striatum assessed with in vivo microdialysis: Relationship to behavior", SYNAPSE, 33(1), 1999, pp. 16-25

Abstract

Effects of i.c.v. administration of 5,7-dihydroxytryptamine (5,7-DHT) on biochemistry and behavior were studied in awake Sprague-Dawley rats. It was found that 5,7-DHT depletion of striatal tissue levels of serotonin (5-HT) does not diminish extracellular levels until substantial depletions occur. This finding is similar to those observed after 6-hydroxydopamine lesions of the brain dopamine systems. Although varying amounts of 5,7-DHT produced serotonin depletions in striatal tissue, decreases in extracellular levels were only observed at tissue depletions greater than 60% compared to saline-injected control subjects. Thus, the effects of serotonin lesions which produce only moderate depletions may not be the result of decreased extracellular serotonin, but instead may be the result of compensatory changes in remaining neurons which maintain normal extracellular serotonin concentrations. Different degrees of striatal serotonin depletion were associated with opposite behavioral effects. Moderate levels of serotonin depletion (50-75%)produced evidence of increased anxiety, while these effects were no longerseen in rats with more severe 5-HT depletions (>75%). Synapse 33:16-25, 1999. (C) 1999 Wiley-Liss, Inc.

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Documento generato il 29/03/20 alle ore 09:31:56